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JoAnn E. Manson, MD, DrPH, is Chief of the Division of Preventive Medicine, as well as Co-Director of the Connors Center for Women’s Health and Gender Biology, Brigham and Women’s Hospital, Harvard Medical School. She is the Elizabeth Fay Brigham Professor of Women’s Health and Professor of Medicine at Harvard Medical School.

Biography

Education

Dr. Manson received her B.A. from Harvard University, her M.D. from Case Western Reserve University School of Medicine, and an M.P.H. and Dr.P.H. from the Harvard School of Public Health.

Career

Dr. Manson is board certified in both Internal Medicine and the subspecialty of Endocrinology and Metabolism. Her major research interests include preventive medicine and chronic disease epidemiology, particularly risk factors for cardiovascular disease, diabetes, and cancer in women. She is Principal Investigator of several grants from the National Institutes of Health, including the Women’s Health Initiative Vanguard Clinical Center at Brigham and Women’s Hospital in Boston, Women’s Antioxidant and Folic Acid Cardiovascular Trial, Biochemical and Genetic Risk Factors for CVD in Women, and the Vitamin D and Omega-3 Trial, among others. She is also Principal Investigator of the Boston site for the Kronos Early Estrogen Prevention Study. Dr. Manson is a member of many professional societies and serves on the editorial/medical advisory boards of several medical journals.

She has published more than 700 articles in the medical literature, and is the editor-in-chief of the textbook, Prevention of Myocardial Infarction, published in 1996 by Oxford Univ. Press, and Clinical Trials in Heart Disease, published by Elsevier Saunders in 2004. She is also author of The 30-Minute Fitness Solution (Harvard Univ. Press, 2001) and Hot Flashes, Hormones, & Your Health (McGraw-Hill, 2007). She has also edited or co-edited six other textbooks.

Research

The focus of Dr. Manson’s research has been women's health, particularly the role of lifestyle factors, diet, micronutrient supplementation, and hormone replacement therapy as predictors of cardiovascular disease in women. Other major interests include the role of vitamin D, omega-3s, and folate in the prevention of CVD, diabetes, and cancer, and assessment of endocrinologic predictors of breast cancer. In several large scale prospective cohort studies and randomized clinical trials, Dr. Manson has assessed the role of lifestyle factors and therapeutic interventions in the prevention of chronic disease in women. She has studied extensively the role of moderate-intensity exercise as compared with vigorous exercise in the prevention of heart disease, stroke, type 2 diabetes, and breast cancer in women. She has also been actively involved in studies of biomarker and genetic predictors of cardiovascular disease and diabetes. She is one of the lead investigators on several landmark women’s health studies, including the Women’s Health Initiative, the Nurses’ Health Study, the Women’s Antioxidant and Folic Acid Cardiovascular Study, and the Women’s Health Study.

Awards and Recognition

Dr. Manson has received numerous awards and honors, including being named one of ten Heroes in Women’s Health by American Health for Women magazine in 1997, one of the top ten “Champions of Women’s Health” by Ladies Home Journal in 2000, one of Boston’s “Top Docs for Women” by Boston Magazine in 2001, the Henry Ingersoll Bowditch Award for Excellence in Public Health from the Massachusetts Medical Society in 2002, the “Woman in Science” Award from the American Medical Women’s Association in 2003, election to membership in the Association of American Physicians in 2005, fellowship in the American Association for the Advancement of Science, the Harvard College Women’s Professional Achievement Award in 2006, the North American Menopause Society’s Postmenopausal Cardiovascular Health Research Award in 2007, and the International Menopause Society’s Henry Burger Research Prize in 2008. Dr. Manson was one of the physicians featured in the National Library of Medicine’s exhibition, “History of American Women Physicians”, in Bethesda, Maryland.

Selected Publications

Books

The 30-Minute Fitness Solution : A Four-Step Plan For Women of All Ages. Cambridge, Mass., Harvard University Press. 2001. ISBN 0674004795

Hot Flashes, Hormones, and Your Health. New York, McGraw-Hill. 2006. ISBN 0071468625

Articles and Essays

1. Manson JE, Stampfer MJ, Hennekens CH, Willett WC. Body weight and longevity: a reassessment. JAMA 1987; 257:353-358.

2. Manson JE, Stampfer MJ, Colditz GA, Willett WC, Rosner B, Speizer FE, Hennekens CH. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med 1990;322:882-889.

3. Manson JE, Colditz GA, Stampfer MJ, Willett WC, Kroleswki AS, Rosner B, Arky RA, Speizer FE, Hennekens CH. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med; 1991; 151:1141-1147.

4. Manson JE, Stampfer MJ, Colditz GA, et al. A prospective study of aspirin use and primary prevention of cardiovascular disease in women. JAMA 1991; 266:521-27.

5. Manson, JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Kroleswki AS, Rosner B, Hennekens CH, Speizer FE. A prospective study of physical activity and incidence of noninsulin-dependent diabetes mellitus in women. Lancet 1991; 338: 774-8.

6. Manson JE, Tosteson H, Ridker PM, Satterfield S, Hebert P, O'Connor GT, Buring JE, Hennekens CH. Medical Progress: Primary prevention of myocardial infarction. N Engl J Med 1992; 326:1406-16.

7. Manson JE, Rimm EB, Colditz GA, et al. A prospective study of postmenopausal estrogen therapy and subsequent incidence of noninsulin-dependent diabetes mellitus. Ann Epidemiol 1992; 2:665-73.

8. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH. A prospective study of exercise and incidence of diabetes in U.S. male physicians. JAMA 1992; 268:63-7.

9. Hankinson SE, Manson JE, London ST, Willett WC, Speizer FE. Laboratory reproducibility of endogenous hormone levels in postmenopausal women. Canc Epidemiol Bio Prev 1993; 3:51-6.

10. Manson JE, Willett WC, Stampfer MJ, Colditz GA, Hunter DJ, Hankinson SE, Hennekens CH, Speizer FE. Body weight and mortality among women. N Engl J Med 1995; 333:677-85.

11. Grodstein F, Stampfer MJ, Manson JE, Colditz GA, Willett WC, Rosner B, Speizer FE, Hennekens CH. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 1996; 335:453-61.

12. Manson JE, Hu FB, Rich-Edwards JW, Colditz GA, Stampfer MJ, Willett WC, Speizer FE, Hennekens CH. A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med 1999; 341:650-8.

13. Ridker PM, Manson JE, Buring JE, Shih J, Matias M, Hennekens CH. A prospective study of homocysteine and the risk of cardiovascular disease among postmenopausal women. JAMA 1999; 281:1817-21.

14. Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000; 343:16-22.

15. Manson JE, Greenland P, LaCroix AZ, et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 2002; 347:716-725.

16. Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, et al. for the Women’s Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003; 349:523-534.

17. Margolis KL, Manson JE, Greenland P, Rodabough RJ, Bray PF, Safford M, Grimm RH, Howard BV, Assaf AR, Prentice R. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women. Arch Intern Med 2005; 165: 500-508.323.

18. Ridker PM, Cook NR, Lee I-M, Gordon D, Gaziano JM, Manson JE, Hennekens CH, Buring JE. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005; 352:1293-1304. 358.

19. Mantzoros CS, Li T, Manson JE, Meigs J, Hu FB. Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile and reduced inflammation in women with type 2 diabetes. J Clin Endocrin Metab 2005; 90:4542-4548.

20. Asselbergs FW, Pai JK, Pischon T, Manson JE, Rimm EB. Thrombospondin-4 Ala387Pro polymorphism is not associated with vascular function and risk of coronary heart disease in US men and women. Thromb Haemost 2006; 95(3):589-590. 384.

21. Pai JK, Kraft P, Cannuscio CC, Manson JE, Rexrode KM, Albert CM, Hunter D, Rimm EB. Poly- morphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US women. Atherosclerosis 2006;186(1):132-139.

22. Sun Q, Ma J, Campos H, Hankinson SE, Manson JE, Stampfer MJ, Rexrode KM, Willett WC, Hu FB. A prospective study of trans fatty acids in erythrocytes and risk of coronary heart disease. Circulation 2007; 115(14):1858-65.

23. Manson JE, Allison MA, Rossouw JE, Carr JJ, Langer RD, Hsia J, et al. Estrogen therapy and coronary-artery calcification. N Engl J Med 2007; 356:2591-2602.

24. Albert CM, Cook NR, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE. Manson JE. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease. JAMA 2008; 299(17):2027-2036.

25. Pischon T, Hu FB, Rexrode KM, Girman CJ, Manson JE, Rimm EB. Inflammation, the metabolic syndrome, and risk of coronary heart disease in women and men. Atherosclerosis 2008; 197(1):392-399.

26. Sesso HD, Buring JE, Christen WG, Kurth T, Belanger C, MacFadyen J, Bubes V, Manson JE, Glynn RF, Gaziano JM. Vitamins E and C in the prevention of cardiovascular disease in men. The Physicians’ Health Study II Randomized Controlled Trial. JAMA 2008; 300(18):2123-2133.

References

http://www.hsph.harvard.edu/faculty/joann-manson/

http://www.brighamandwomens.org/preventivemedicine/Faculty/Manson.aspx

http://www.time.com/time/2004/obesity/speakers/manson.html

http://www.nlm.nih.gov/changingthefaceofmedicine/physicians/biography_212.html

External Links

General

THE VITAMIN D AND OMEGA-3 TRIAL (VITAL)

Monthly Glamour Column "Your Doctor Is In"

Video

| Vitamins and Your Health

http://www.nlm.nih.gov/changingthefaceofmedicine/video/212_1.html

http://www.msnbc.msn.com/id/21134540/vp/16524059#16524059

Selected Writings

• Unreferenced BLPs from September 2009
• 1953 births
• Living people