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| '''Arieh Warshel''' is a Distinguished Professor of Chemistry and Biochemistry at the ].<ref>{{cite web|url=http://www.usc.edu/about/faculty/distinguished_professors.html|title=The University of Southern California Distinguished Professors|accessdate=2011-01-24| archiveurl= http://web.archive.org/web/20110226035259/http://www.usc.edu/about/faculty/distinguished_professors.html| archivedate= 26 February 2011 <!--DASHBot-->| deadurl= no}}</ref> He is known for his work on computational biochemistry and biophysics, and, in particular, for having pioneered computer simulations of the function of biological systems |
'''Arieh Warshel''' is a Distinguished Professor of Chemistry and Biochemistry at the ].<ref>{{cite web|url=http://www.usc.edu/about/faculty/distinguished_professors.html|title=The University of Southern California Distinguished Professors|accessdate=2011-01-24| archiveurl= http://web.archive.org/web/20110226035259/http://www.usc.edu/about/faculty/distinguished_professors.html| archivedate= 26 February 2011 <!--DASHBot-->| deadurl= no}}</ref> He is known for his work on computational biochemistry and biophysics, and, in particular, for having pioneered computer simulations of the function of biological systems. He is also one of the pioneers in developing what is now known as Computational Enzymology. | ||
| Arieh Warshel was born in Kibbutz Sde-Nahum in Israel in 1940. After serving in the Israeli Army (final rank Captain), he attended the Technion in Haifa, where he received his BSc degree in Chemistry, Summa Cum Laude, in 1966. He subsequently earned both MSc and PhD degrees in Chemical Physics (1967 and 1969 respectively) from the Weizmann Institute of Science, together with Shneior Lifson. After his PhD, he did postdoctoral work at Harvard University. From 1972 to 1976, he was at the Weizmann Institute and at the MRC Laboratory for Molecular Biology in Cambridge, England. In 1976, he joined the faculty of the Department of Chemistry at USC, where he is a Distinguished Professor of Chemistry and Biochemistry. | Arieh Warshel was born in Kibbutz Sde-Nahum in Israel in 1940. After serving in the Israeli Army (final rank Captain), he attended the Technion in Haifa, where he received his BSc degree in Chemistry, Summa Cum Laude, in 1966. He subsequently earned both MSc and PhD degrees in Chemical Physics (1967 and 1969 respectively) from the Weizmann Institute of Science, together with Shneior Lifson. After his PhD, he did postdoctoral work at Harvard University. From 1972 to 1976, he was at the Weizmann Institute and at the MRC Laboratory for Molecular Biology in Cambridge, England. In 1976, he joined the faculty of the Department of Chemistry at USC, where he is a Distinguished Professor of Chemistry and Biochemistry. | ||
| Warshel has been elected a member <ref>{{cite web|url=http://dornsife.usc.edu/news/stories/558/arieh-warshel-elected-to-the-national-academy-of-sciences|title=Arieh Warshel Elected to the National Academy of Sciences|accessdate=2011-03-31}}</ref> of the ], a fellow <ref>{{cite web|url=http://dornsife.usc.edu/news/stories/539/arieh-warshel-elected-to-royal-society-of-chemistry|title=Arieh Warshel Elected to Royal Society of Chemistry|accessdate=2011-03-31}}</ref> of the ] (FRSC), and a fellow of the Biophysical Society (2000). He was additionally awarded the Technion Award for best third-year student in Chemistry (1965), the Mifal-Hapays Prize (1969), the Alfred P. Sloan Fellowship (1978-1980), the USC Associated Award for Creativity in Research (1981), the 1993 Annual Award of the International Society of Quantum Biology and Pharmacology, the Tolman Medal (2003), |
Warshel has been elected a member <ref>{{cite web|url=http://dornsife.usc.edu/news/stories/558/arieh-warshel-elected-to-the-national-academy-of-sciences|title=Arieh Warshel Elected to the National Academy of Sciences|accessdate=2011-03-31}}</ref> of the ], a fellow <ref>{{cite web|url=http://dornsife.usc.edu/news/stories/539/arieh-warshel-elected-to-royal-society-of-chemistry|title=Arieh Warshel Elected to Royal Society of Chemistry|accessdate=2011-03-31}}</ref> of the ] (FRSC), and a fellow of the Biophysical Society (2000). He was additionally awarded the Technion Award for best third-year student in Chemistry (1965), the Mifal-Hapays Prize (1969), the Alfred P. Sloan Fellowship (1978-1980), the USC Associated Award for Creativity in Research (1981), the 1993 Annual Award of the International Society of Quantum Biology and Pharmacology, the Tolman Medal (2003), the 2006 President’s Award for Computational Biology from the ISQBP, and the 2012 RSC Soft Matter and Biophysical Chemistry Award. | ||
| ==Research Achievements== | |||
| {{example farm}} | |||
| Warshel has made major contributions in introducing computational methods for studying structure-function correlation in biological molecules. He pioneered (and co-pioneered) simulation software, as well as key methods and concepts for microscopic studies of the functional properties of biological molecules, including the Cartesian-based force field program CFF <ref name=cons1>{{cite journal |author=Lifson S, Warshel A.|year= 1968| title=A Consistent Force Field for Calculation on Conformations, Vibrational Spectra and Enthalpies of Cycloalkanes and n-Alkane Molecules| journal = J. Phys. Chem.| volume=49| pages=5116| doi=10.1063/1.1670007 |issue=11}}</ref><ref name=cons2>{{cite journal |author=Warshel A, Lifson S.|year=1970| title=Consistent Force Field Calculations. II. Crystal Structure, Sublimation Energies, Molecular and Lattice Vibrations, Molecular Conformations and Enthalpies of Alkanes| journal= J. Chem. Phys.| volume=53| pages=582| doi=10.1063/1.1674031 |issue=2}}</ref><ref name=lev01> {{cite journal|author=Levitt, M|year=2001|title=The birth of computational structural biology|journal=Nat. Struct. Biol.|volume=8|pages=392–393|doi=10.1038/87545|pmid=11323711}}</ref>, the QM/MM method for simulating enzymatic reactions, <ref name="warshel">{{cite journal| author=Warshel A, Levitt M| year=1976| title=Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme| journal=J. Mol. Biol.| volume=103| pages=227–49| doi=10.1016/0022-2836(76)90311-9| pmid=985660| issue=2}}</ref>, molecular dynamics simulations of biological molecules <ref name="bicycle">{{cite journal |author=Warshel A.| year=1976| title=Bicycle-pedal Model for the First Step in the Vision Process| journal=Nature| volume=260|pages=679–83| doi=10.1038/260679a0 |pmid=1264239 |issue=5553}}</ref><ref name=moldyn>{{cite journal |author=Warshel A.| year=2002|title=Molecular Dynamics Simulations of Biological Reactions| journal=Acc. Chem. Res.| volume=35|pages=385–395|doi=10.1021/ar010033z |pmid=12069623 |issue=6}}</ref>, microscopic electrostatic models for proteins <ref name="warshel">{{cite journal| author=Warshel A, Levitt M| year=1976| title=Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme| journal=J. Mol. Biol.| volume=103| pages=227–49| doi=10.1016/0022-2836(76)90311-9| pmid=985660| issue=2}}</ref><ref name=russ>{{cite journal| author=Warshel A, Russell S T.| year=1984|title=Calculations of Electrostatic Interactions in Biological Systems and in Solutions| journal=Quart. Rev. Biophys.| volume=17|pages=283| doi=10.1017/S0033583500005333| issue=3}}</ref>, free energy perturbations in proteins <ref name=simul>{{cite journal|author=Warshel A|year=1984|title=Simulating the Energetics and Dynamics of Enzymatic Reactions|journal=Pontificiae Academiae Scientiarum Scripta Varia| volume=55|pages=60}}</ref>, and other key advances. His contributions include quantifying the molecular basis for enzyme catalysis by both providing the tools for calculating catalysis <ref name="warshel">{{cite journal| author=Warshel A, Levitt M| year=1976| title=Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme| journal=J. Mol. Biol.| volume=103| pages=227–49| doi=10.1016/0022-2836(76)90311-9| pmid=985660| issue=2}}</ref><ref name=getics>{{cite journal| author=Warshel A| year=1978| title=Energetics of enzyme catalysis| journal=Proc. Natl. Acad. Sci. USA| volume=75| pages=5250–4| doi=10.1073/pnas.75.11.5250| pmid=281676| issue=11| pmc=392938}}</ref><ref name=chemrev> {{cite journal|title=Electrostatic Basis for Enzyme Catalysis|author=Warshel A, Sharma P K, Kato M, Xiang Y, Liu H, Olsson M H M|journal=Chemical Reviews| year=2006|volume=106|issue=8| pages=3210–3235|doi=10.1021/cr0503106|pmid=16895325}}</ref><ref>{{cite journal|doi=10.1073/pnas.97.22.11899|year=2000|volume =97|issue=22|pages= 11899–11904|title=How important are entropic contributions to enzyme catalysis?|author=Villà J, Štrajbl M,Glennon T M,Sham Y Y,Chu Z T, Warshel A|pmid=11050223|pmc=17266}} </ref><ref> {{cite book|title= Computer Simulation of Chemical Reactions in Enzymes and Solutions|author= Warshel A|publisher=John Wiley & Sons|year=1991|place=New York}} </ref> and establishing that enzyme catalysis is due to the fact that the active site dipoles are already preoriented towards the charge distribution of the transition state <ref name=getics>{{cite journal| author=Warshel A| year=1978| title=Energetics of enzyme catalysis| journal=Proc. Natl. Acad. Sci. USA| volume=75| pages=5250–4| doi=10.1073/pnas.75.11.5250| pmid=281676| issue=11| pmc=392938}}</ref>. | |||
| ==References== | ==References== | ||
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| Arieh Warshel | |
|---|---|
 | |
| Born | (1940-11-20) November 20, 1940 (age 84) Kibbutz Sde-Nahum, Israel |
| Nationality | Israeli, American |
| Citizenship | Israel, United States |
| Alma mater | Technion, Weizmann Institute |
| Known for | computational enzymology, electrostatics, enzyme catalysis |
| Scientific career | |
| Fields | Chemistry, Biochemistry, Biophysics |
| Institutions | University of Southern California, Weizmann Institute, MRC Laboratory of Molecular Biology |
Arieh Warshel is a Distinguished Professor of Chemistry and Biochemistry at the University of Southern California. He is known for his work on computational biochemistry and biophysics, and, in particular, for having pioneered computer simulations of the function of biological systems. He is also one of the pioneers in developing what is now known as Computational Enzymology.
Arieh Warshel was born in Kibbutz Sde-Nahum in Israel in 1940. After serving in the Israeli Army (final rank Captain), he attended the Technion in Haifa, where he received his BSc degree in Chemistry, Summa Cum Laude, in 1966. He subsequently earned both MSc and PhD degrees in Chemical Physics (1967 and 1969 respectively) from the Weizmann Institute of Science, together with Shneior Lifson. After his PhD, he did postdoctoral work at Harvard University. From 1972 to 1976, he was at the Weizmann Institute and at the MRC Laboratory for Molecular Biology in Cambridge, England. In 1976, he joined the faculty of the Department of Chemistry at USC, where he is a Distinguished Professor of Chemistry and Biochemistry.
Warshel has been elected a member of the United States National Academy of Sciences, a fellow of the Royal Society of Chemistry (FRSC), and a fellow of the Biophysical Society (2000). He was additionally awarded the Technion Award for best third-year student in Chemistry (1965), the Mifal-Hapays Prize (1969), the Alfred P. Sloan Fellowship (1978-1980), the USC Associated Award for Creativity in Research (1981), the 1993 Annual Award of the International Society of Quantum Biology and Pharmacology, the Tolman Medal (2003), the 2006 President’s Award for Computational Biology from the ISQBP, and the 2012 RSC Soft Matter and Biophysical Chemistry Award.
Research Achievements
| This article may contain excessive or irrelevant examples. Please help improve the article by adding descriptive text and removing less pertinent examples. |
Warshel has made major contributions in introducing computational methods for studying structure-function correlation in biological molecules. He pioneered (and co-pioneered) simulation software, as well as key methods and concepts for microscopic studies of the functional properties of biological molecules, including the Cartesian-based force field program CFF , the QM/MM method for simulating enzymatic reactions, , molecular dynamics simulations of biological molecules , microscopic electrostatic models for proteins , free energy perturbations in proteins , and other key advances. His contributions include quantifying the molecular basis for enzyme catalysis by both providing the tools for calculating catalysis and establishing that enzyme catalysis is due to the fact that the active site dipoles are already preoriented towards the charge distribution of the transition state .
References
- "The University of Southern California Distinguished Professors". Archived from the original on 26 February 2011. Retrieved 2011-01-24.
{{cite web}}: Unknown parameter|deadurl=ignored (|url-status=suggested) (help) - "Arieh Warshel Elected to the National Academy of Sciences". Retrieved 2011-03-31.
- "Arieh Warshel Elected to Royal Society of Chemistry". Retrieved 2011-03-31.
- Lifson S, Warshel A. (1968). "A Consistent Force Field for Calculation on Conformations, Vibrational Spectra and Enthalpies of Cycloalkanes and n-Alkane Molecules". J. Phys. Chem. 49 (11): 5116. doi:10.1063/1.1670007.
- Warshel A, Lifson S. (1970). "Consistent Force Field Calculations. II. Crystal Structure, Sublimation Energies, Molecular and Lattice Vibrations, Molecular Conformations and Enthalpies of Alkanes". J. Chem. Phys. 53 (2): 582. doi:10.1063/1.1674031.
- Levitt, M (2001). "The birth of computational structural biology". Nat. Struct. Biol. 8: 392–393. doi:10.1038/87545. PMID 11323711.
- ^ Warshel A, Levitt M (1976). "Theoretical Studies of Enzymatic Reactions: Dielectric Electrostatic and Steric Stabilization of the Carbonium Ion in the Reaction of Lysozyme". J. Mol. Biol. 103 (2): 227–49. doi:10.1016/0022-2836(76)90311-9. PMID 985660.
- Warshel A. (1976). "Bicycle-pedal Model for the First Step in the Vision Process". Nature. 260 (5553): 679–83. doi:10.1038/260679a0. PMID 1264239.
- Warshel A. (2002). "Molecular Dynamics Simulations of Biological Reactions". Acc. Chem. Res. 35 (6): 385–395. doi:10.1021/ar010033z. PMID 12069623.
- Warshel A, Russell S T. (1984). "Calculations of Electrostatic Interactions in Biological Systems and in Solutions". Quart. Rev. Biophys. 17 (3): 283. doi:10.1017/S0033583500005333.
- Warshel A (1984). "Simulating the Energetics and Dynamics of Enzymatic Reactions". Pontificiae Academiae Scientiarum Scripta Varia. 55: 60.
- ^ Warshel A (1978). "Energetics of enzyme catalysis". Proc. Natl. Acad. Sci. USA. 75 (11): 5250–4. doi:10.1073/pnas.75.11.5250. PMC 392938. PMID 281676.
- Warshel A, Sharma P K, Kato M, Xiang Y, Liu H, Olsson M H M (2006). "Electrostatic Basis for Enzyme Catalysis". Chemical Reviews. 106 (8): 3210–3235. doi:10.1021/cr0503106. PMID 16895325.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Villà J, Štrajbl M,Glennon T M,Sham Y Y,Chu Z T, Warshel A (2000). "How important are entropic contributions to enzyme catalysis?". 97 (22): 11899–11904. doi:10.1073/pnas.97.22.11899. PMC 17266. PMID 11050223.
{{cite journal}}: Cite journal requires|journal=(help)CS1 maint: multiple names: authors list (link) - Warshel A (1991). Computer Simulation of Chemical Reactions in Enzymes and Solutions. New York: John Wiley & Sons.