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| ==History== | ==History== | ||
| ] at the ] attained departmental status in 1974 and opened its first building on the USC Health Sciences Campus in 1975. Although an ophthalmology residency program existed at USC prior to that time, there were no full-time faculty members in the department. | |||
| ] at the ] attained departmental status in 1974 and opened its first building on the USC Health Sciences Campus in 1975. Although an ophthalmology residency program existed at USC prior to that time, there were no full-time faculty members in the department. Stephen J. Ryan was recruited in 1974 and served as the department’s first professor and chairman through 1995.<ref>{{cite web|url= http://articles.latimes.com/2013/may/05/local/la-me-stephen-ryan-20130506|title= Stephen J. Ryan dies at 73; longtime dean of USC medical school|publisher='']'' |date=2013-05-05|accessdate=2015-01-07}}</ref> In 1975, the Doheny Eye Institute<ref>. Doheny.org.</ref> allied with USC's Ophthalmology department under Ryan and relocated to the USC campus. The alliance "provided Dr. Ryan the opportunity to recruit and build the institute’s department from the ground up. Thus began the transformation of the institute into one of the top university based ophthalmic teaching, clinical, and research centers....Dr. Ryan built Doheny into a respected institution. In 2011 alone, Doheny scientists received $21.8 million in federal and state grants and published more than 180 scientific papers."<ref>Linda Roach for Eyenet Magazine. June 2013. </ref> All of the Doheny Eye Institute's doctors were appointed as USC faculty members.<ref name=Law360oct>Alex Ortolani For Law360. October 28, 2011</ref> | |||
| The Doheny Eye Institute built a new building on USC's campus in 1985 to provide clinical facilities for USC's ophthalmology faculty.<ref></ref> | The Doheny Eye Institute built a new building on USC's campus in 1985 to provide clinical facilities for USC's ophthalmology faculty.<ref></ref> | ||
| Line 53: | Line 53: | ||
| In December 2013 David Hinton and Mark S. Humayun won a $19 million grant from the ] to conduct a clinical trial in which the use of ]s to treat ] will be tested.<ref>{{cite web|url= http://stemcell.usc.edu/2013/12/16/clinical-trial-to-study-loss-of-vision/ | title=Clinical trial to study loss of vision |publisher=ResearchGate |date=2013-12-16 |accessdate=2015-01-11}}</ref> | In December 2013 David Hinton and Mark S. Humayun won a $19 million grant from the ] to conduct a clinical trial in which the use of ]s to treat ] will be tested.<ref>{{cite web|url= http://stemcell.usc.edu/2013/12/16/clinical-trial-to-study-loss-of-vision/ | title=Clinical trial to study loss of vision |publisher=ResearchGate |date=2013-12-16 |accessdate=2015-01-11}}</ref> | ||
| ==''Breakthroughs and Advances in Vision Research and Patient Care''== | |||
| * Bulleted list item | |||
| USC Eye Institute ranked in Top Ten by U.S. News and World Report each year since rankings began in 1993 | |||
| * Bulleted list item | |||
| Ranked in Top Ten by Ophthalmology Times since rankings began in 1996 | |||
| * Bulleted list item | |||
| Ranked in Top Ten grant funding from NEI to Ophthalmology Departments and Eye Research Institutes for many years | |||
| ==''Significant Achievements by USC Eye Institute Faculty Members'' == | |||
| * Bulleted list item | |||
| Awarded more than 60 patents for innovations in eye care and vision research | |||
| * Bulleted list item | |||
| Identified the retinoblastoma gene responsible for the leading cause of ocular cancer in children (Murphree) | |||
| * Bulleted list item | |||
| Showed the importance of oxygen radicals in causing retinal damage in uveitis (2005) (Rao) | |||
| * Bulleted list item | |||
| Described and suggested treatment for a blinding viral infection of the retina and named the new entity “Progressive Outer Retinal Necrosis” (1990) (Rao) | |||
| * Bulleted list item | |||
| Diagnosed and developed treatments for various opportunistic infections in the eyes of patients with AIDS (1991) (Rao) | |||
| * Bulleted list item | |||
| Showed the incidence of Kaposi’s sarcoma, an eye malignancy, and developed treatment options (1992) (Rao) | |||
| * Bulleted list item | |||
| Developed a model of the complex interactions that occur in Graves’ thyroid eye disease (1998) (Feldon) | |||
| * Bulleted list item | |||
| Proved that toxic, nutritional, and metabolic optic nerve disease are related to injuries to the mitochondria of nerve cells (1994) (Sadun) | |||
| * Bulleted list item | |||
| Discovered that the cytokine tumor necrosis factor mediates apoptosis (cell death) in retinal ganglion cells, which may reflect the mechanism for some optic neuropathies (1996) (Sadun) | |||
| * Bulleted list item | |||
| Discovered that changes to the optic nerve mirror the changes to the brain that occur in Alzheimer’s (1989) (Sadun) | |||
| * Bulleted list item | |||
| Asked by a head of state to investigate a country’s epidemic of blindness (Cuba) (1993) (Sadun) | |||
| * Bulleted list item | |||
| Determined the causes of blindness and eye disease in a population study of Latinos (Varma) | |||
| * Bulleted list item | |||
| Identified electrolyte transport processes that drive formation of tear fluid in the lacrimal gland | |||
| * Bulleted list item | |||
| Implanted the first successful retinal prosthesis in humans (Humayun, Weiland) | |||
| * Bulleted list item | |||
| Demonstrated the role of low androgen levels in the pathogenesis of dry eye | |||
| * Bulleted list item | |||
| Discovered a novel retinal protein that may play a role in retinal degenerations such as macular degeneration (Fong) | |||
| * Bulleted list item | |||
| Developed a new computerized system to analyze retinal images for the diagnosis and management of macular degeneration and diabetic retinopathy (Sadda) | |||
| * Bulleted list item | |||
| Pioneered the study of applying medication directly into the sub retinal space to treat wet macular degeneration | |||
| * Bulleted list item | |||
| Received the first National Science Foundation Engineering Research Center grant awarded to an ophthalmologist (or any M.D.) (Humayun) | |||
| * Bulleted list item | |||
| Developed the first internet-based screening visual field test (including a 3-D version) (2000-2003) | |||
| * Bulleted list item | |||
| Described the anterior slit-lamp procedure for aqueous misdirection glaucoma | |||
| * Bulleted list item | |||
| First demonstrated the in vitro flow properties of aqueous tube shunts | |||
| * Bulleted list item | |||
| First to use a commercial prototype of an adaptive optics scanning laser ophthalmoscope (cone photoreceptors can be imaged) | |||
| * Bulleted list item | |||
| First to use a commercial prototype of an adaptive optics scanning laser ophthalmoscope (cone photoreceptors can be imaged) | |||
| * Bulleted list item | |||
| First analyzed the comparative histopathology of external and endoscopic cyclophotocoagulation (with UCSF) | |||
| * Bulleted list item | |||
| Developed a laboratory model of penetrating eye injuries that influences the management of trauma in humans (Ryan, Hinton, He) (1978) | |||
| * Bulleted list item | |||
| Developed a laboratory model of choroidal neovascularization now widely used to study pathogenesis and treatment of subretinal neovascularization (Ryan, Hinton, He) (1979) | |||
| * Bulleted list item | |||
| Developed a widely-used aqueous tube shunt for glaucoma patients (Baerveldt) | |||
| * Bulleted list item | |||
| Discovered the potential antigen-presenting function of lacrimal gland secretory epithelial cells | |||
| * Bulleted list item | |||
| Developed an animal mode of autoimmune dacryoadenitis that mimics Sjorgen’s Syndrome (2002-2007) (Trousdale) | |||
| * Bulleted list item | |||
| Demonstrated the potential value of gene therapy for dry eye in an animal model of autoimmune dacryoadenitis | |||
| * Bulleted list item | |||
| Proposed and studied a new theory of dry eye as a local ocular surface autoimmune disease (Mircheff) | |||
| * Bulleted list item | |||
| Implanted the first intraocular-sustained drug delivery device into human eyes west of the Mississippi (Phase I study of gancioclovir implant) | |||
| ◊ Developed and implanted the first intraocular radiation delivery device to be used in a human | |||
| ◊ Identified the mechanism and pathways (cytokines, transforming factors) of corneal fibrosis (Kay, Smith) | |||
| ◊ Identified the cascade from injury-mediated corneal inflammation to the final stage of the wound healing (Kay, Smith) | |||
| ◊ Developed the first head-mounted display visual field testing device (2005) | |||
| ◊ First clinical trial on intra-ocular brachytherapy for neovascular AMD | |||
| ◊ Development of a long-term intra-ocular drug delivery platform | |||
| ◊ Developed an intraocular pressure-sensing device that can be implanted or worn externally to obtain IOP data continuously and report data to a remote source | |||
| ◊ Pioneered the use of ultra-high-speed Fourier domain OCT in glaucoma diagnosis (2000-2010) (Huang) | |||
| ◊ Demonstrated the impaired orthograde and retrograde axonal flow in lamina cribrosa in experimental glaucoma (Minckler) | |||
| ◊ Found that axonal transport obstruction causes disc swelling in ocular hypotony | |||
| ◊ Discovered that a decrease in axonal bundles in the optic nerve with aging correlates with the visual decline of aging (1987) | |||
| ◊ Developed the vertical prism test that is widely used to diagnose amblyopia in preverbal children | |||
| ◊ Developed the superior oblique tendon expander used in surgery for Brown syndrome and superior oblique over action (about 1990) | |||
| ◊ Demonstrated the use of high-speed optical coherence tomography in the management of corneal scars, angle closure glaucoma, keratorefractive surgery and IOL implants | |||
| ◊ Demonstrated the clinical applications of very high-speed Fourier- domain optical coherence tomography in macular and optic nerve diseases | |||
| ◊ Developed and characterized the first animal model of “meibomian gland dysfunction” (Smith, Nicolaides) | |||
| ◊ Developed infrared photography of the meibomian glands “meibography” for research and clinical use. (Jester, Smith, Nicolaides) | |||
| ◊ Regularly reported the changing indications for penetrating keratoplasty in Southern California (Smith, Rao) | |||
| ◊ Developed a noninvasive glucose monitoring system using Raman spectrum signals from the aqueous (Borchert) | |||
| ◊ Characterized largest pedigree of Lebers hereditary optic neuropathy (2001) (Sadun) | |||
| ◊ Evaluated potent antiviral drugs for ophthalmic use (Trousdale) | |||
| ◊ Made contributions that improved the formulation of commercial cornea storage medium | |||
| ◊ First video rate hyperspectral imaging of the retina in patients | |||
| ◊ First publication on large scale clinical surgical results with B+L TSV 25 gauge vitrectomy system | |||
| ◊ Contributed to development of treatment of astigmatism using excimer laser (McDonnell) | |||
| ◊ Identified unique mechanism of uptake in lacrimal gland for adenovirus 5 that may facilitate drug delivery (Hamm-Alvarez) | |||
| ◊ Initiated work on the development of an artificial lacrimal gland (2004) | |||
| ◊ Developed first genetic animal model of Leber’s Hereditary Optic Neuropathy (2012) (Sadun) | |||
| First West Coast provider of the PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem) – a scleral device treatment (2009) (Chiu, Irvine) | |||
| ==''U.S. News & World Report''== | ==''U.S. News & World Report''== | ||
Revision as of 23:13, 19 February 2015
Hospital in California, United States| USC Eye Institute | |
|---|---|
| Geography | |
| Location | Los Angeles, California, United States |
| Organization | |
| Funding | Private |
| Type | Teaching |
| Affiliated university | University of Southern California (USC) Keck School of Medicine of USC |
| Services | |
| Speciality | Ophthalmology |
| Links | |
| Website | eye |
| Lists | Hospitals in California |
The USC Eye Institute, part of Keck School of Medicine of USC, is a center for ophthalmic care, research and education located in downtown Los Angeles, California. It has subsidiary clinics in Pasadena, Beverly Hills and Arcadia. It was allied with the Doheny Eye Institute from 1975 until 2013, when Doheny allied with University of California Los Angeles.
History
Ophthalmology at the Keck School of Medicine of USC attained departmental status in 1974 and opened its first building on the USC Health Sciences Campus in 1975. Although an ophthalmology residency program existed at USC prior to that time, there were no full-time faculty members in the department.
The Doheny Eye Institute built a new building on USC's campus in 1985 to provide clinical facilities for USC's ophthalmology faculty.
Ronald E. Smith served as department chairman from 1995 to 2013.
In 2011, USC and the Doheny Eye Institute fell into a dispute over renovations, permits, and other matters related to the building, which led to litigation.
In 2013, the Doheny Eye Institute ended its relationship with USC and entered into an exclusive, long-term affiliation with University of California Los Angeles.
Mark S. Humayun was interim chair of the Department of Ophthalmology at the Keck School of Medicine of USC in November 2013, and in February 2014, Rohit Varma was appointed as director of the USC Eye Institute.
Research
Members of the Institute have made contributions to vision research, some prior to arriving at USC such as two of the inventors of optical coherence tomography, Carmen A. Puliafito (as of 2007, Dean of the Keck School of Medicine) and David Huang, who did his residency at USC.
Dr. Mark Humayun, who joined the faculty of the Keck School of Medicine of USC in 2001, was a co-inventor of a retinal prosthesis that became the basis for the formation of the company, Second Sight, in 1998. Their first-generation implant had 16 electrodes and was implanted in 6 subjects by Humayun at University of Southern California between 2002 and 2004; Humayan has participated in subsequent clinical trials as well.
Ophthalmologist George Baerveldt, while he was at USC, developed the most commonly used glaucoma implant in the world, the Baerveldt glaucoma implant.
In December 2013 David Hinton and Mark S. Humayun won a $19 million grant from the California Institute for Regenerative Medicine to conduct a clinical trial in which the use of embryonic stem cells to treat age-related macular degeneration will be tested.
Breakthroughs and Advances in Vision Research and Patient Care
- Bulleted list item
USC Eye Institute ranked in Top Ten by U.S. News and World Report each year since rankings began in 1993
- Bulleted list item
Ranked in Top Ten by Ophthalmology Times since rankings began in 1996
- Bulleted list item
Ranked in Top Ten grant funding from NEI to Ophthalmology Departments and Eye Research Institutes for many years
Significant Achievements by USC Eye Institute Faculty Members
- Bulleted list item
Awarded more than 60 patents for innovations in eye care and vision research
- Bulleted list item
Identified the retinoblastoma gene responsible for the leading cause of ocular cancer in children (Murphree)
- Bulleted list item
Showed the importance of oxygen radicals in causing retinal damage in uveitis (2005) (Rao)
- Bulleted list item
Described and suggested treatment for a blinding viral infection of the retina and named the new entity “Progressive Outer Retinal Necrosis” (1990) (Rao)
- Bulleted list item
Diagnosed and developed treatments for various opportunistic infections in the eyes of patients with AIDS (1991) (Rao)
- Bulleted list item
Showed the incidence of Kaposi’s sarcoma, an eye malignancy, and developed treatment options (1992) (Rao)
- Bulleted list item
Developed a model of the complex interactions that occur in Graves’ thyroid eye disease (1998) (Feldon)
- Bulleted list item
Proved that toxic, nutritional, and metabolic optic nerve disease are related to injuries to the mitochondria of nerve cells (1994) (Sadun)
- Bulleted list item
Discovered that the cytokine tumor necrosis factor mediates apoptosis (cell death) in retinal ganglion cells, which may reflect the mechanism for some optic neuropathies (1996) (Sadun)
- Bulleted list item
Discovered that changes to the optic nerve mirror the changes to the brain that occur in Alzheimer’s (1989) (Sadun)
- Bulleted list item
Asked by a head of state to investigate a country’s epidemic of blindness (Cuba) (1993) (Sadun)
- Bulleted list item
Determined the causes of blindness and eye disease in a population study of Latinos (Varma)
- Bulleted list item
Identified electrolyte transport processes that drive formation of tear fluid in the lacrimal gland
- Bulleted list item
Implanted the first successful retinal prosthesis in humans (Humayun, Weiland)
- Bulleted list item
Demonstrated the role of low androgen levels in the pathogenesis of dry eye
- Bulleted list item
Discovered a novel retinal protein that may play a role in retinal degenerations such as macular degeneration (Fong)
- Bulleted list item
Developed a new computerized system to analyze retinal images for the diagnosis and management of macular degeneration and diabetic retinopathy (Sadda)
- Bulleted list item
Pioneered the study of applying medication directly into the sub retinal space to treat wet macular degeneration
- Bulleted list item
Received the first National Science Foundation Engineering Research Center grant awarded to an ophthalmologist (or any M.D.) (Humayun)
- Bulleted list item
Developed the first internet-based screening visual field test (including a 3-D version) (2000-2003)
- Bulleted list item
Described the anterior slit-lamp procedure for aqueous misdirection glaucoma
- Bulleted list item
First demonstrated the in vitro flow properties of aqueous tube shunts
- Bulleted list item
First to use a commercial prototype of an adaptive optics scanning laser ophthalmoscope (cone photoreceptors can be imaged)
- Bulleted list item
First to use a commercial prototype of an adaptive optics scanning laser ophthalmoscope (cone photoreceptors can be imaged)
- Bulleted list item
First analyzed the comparative histopathology of external and endoscopic cyclophotocoagulation (with UCSF)
- Bulleted list item
Developed a laboratory model of penetrating eye injuries that influences the management of trauma in humans (Ryan, Hinton, He) (1978)
- Bulleted list item
Developed a laboratory model of choroidal neovascularization now widely used to study pathogenesis and treatment of subretinal neovascularization (Ryan, Hinton, He) (1979)
- Bulleted list item
Developed a widely-used aqueous tube shunt for glaucoma patients (Baerveldt)
- Bulleted list item
Discovered the potential antigen-presenting function of lacrimal gland secretory epithelial cells
- Bulleted list item
Developed an animal mode of autoimmune dacryoadenitis that mimics Sjorgen’s Syndrome (2002-2007) (Trousdale)
- Bulleted list item
Demonstrated the potential value of gene therapy for dry eye in an animal model of autoimmune dacryoadenitis
- Bulleted list item
Proposed and studied a new theory of dry eye as a local ocular surface autoimmune disease (Mircheff)
- Bulleted list item
Implanted the first intraocular-sustained drug delivery device into human eyes west of the Mississippi (Phase I study of gancioclovir implant)
◊ Developed and implanted the first intraocular radiation delivery device to be used in a human
◊ Identified the mechanism and pathways (cytokines, transforming factors) of corneal fibrosis (Kay, Smith)
◊ Identified the cascade from injury-mediated corneal inflammation to the final stage of the wound healing (Kay, Smith)
◊ Developed the first head-mounted display visual field testing device (2005)
◊ First clinical trial on intra-ocular brachytherapy for neovascular AMD
◊ Development of a long-term intra-ocular drug delivery platform
◊ Developed an intraocular pressure-sensing device that can be implanted or worn externally to obtain IOP data continuously and report data to a remote source
◊ Pioneered the use of ultra-high-speed Fourier domain OCT in glaucoma diagnosis (2000-2010) (Huang)
◊ Demonstrated the impaired orthograde and retrograde axonal flow in lamina cribrosa in experimental glaucoma (Minckler)
◊ Found that axonal transport obstruction causes disc swelling in ocular hypotony
◊ Discovered that a decrease in axonal bundles in the optic nerve with aging correlates with the visual decline of aging (1987)
◊ Developed the vertical prism test that is widely used to diagnose amblyopia in preverbal children
◊ Developed the superior oblique tendon expander used in surgery for Brown syndrome and superior oblique over action (about 1990)
◊ Demonstrated the use of high-speed optical coherence tomography in the management of corneal scars, angle closure glaucoma, keratorefractive surgery and IOL implants
◊ Demonstrated the clinical applications of very high-speed Fourier- domain optical coherence tomography in macular and optic nerve diseases
◊ Developed and characterized the first animal model of “meibomian gland dysfunction” (Smith, Nicolaides)
◊ Developed infrared photography of the meibomian glands “meibography” for research and clinical use. (Jester, Smith, Nicolaides)
◊ Regularly reported the changing indications for penetrating keratoplasty in Southern California (Smith, Rao)
◊ Developed a noninvasive glucose monitoring system using Raman spectrum signals from the aqueous (Borchert)
◊ Characterized largest pedigree of Lebers hereditary optic neuropathy (2001) (Sadun)
◊ Evaluated potent antiviral drugs for ophthalmic use (Trousdale)
◊ Made contributions that improved the formulation of commercial cornea storage medium
◊ First video rate hyperspectral imaging of the retina in patients
◊ First publication on large scale clinical surgical results with B+L TSV 25 gauge vitrectomy system
◊ Contributed to development of treatment of astigmatism using excimer laser (McDonnell)
◊ Identified unique mechanism of uptake in lacrimal gland for adenovirus 5 that may facilitate drug delivery (Hamm-Alvarez)
◊ Initiated work on the development of an artificial lacrimal gland (2004)
◊ Developed first genetic animal model of Leber’s Hereditary Optic Neuropathy (2012) (Sadun)
First West Coast provider of the PROSE (Prosthetic Replacement of the Ocular Surface Ecosystem) – a scleral device treatment (2009) (Chiu, Irvine)
U.S. News & World Report
In 2014-15, USC Eye Institute and USC Department of Ophthalmology retained the No. 9 spot in the national rankings of “Best Hospitals” by U.S. News & World Report. The faculty of the USC Department of Ophthalmology has earned Top 10 recognition by the magazine for 20 years.
References
- Alison Trinidad for USC News. December 2, 2014 USC Eye Institute opens new clinic in choice Arcadia location
- University Of Southern California, Plaintiff and Appellant, v. Doheny Eye Institute, Defendant And Respondent. Court Of Appeals Of California, Second District, Division Five. Filed October 18, 2012.
- "Dr. Ronald E. Smith". The Frederick News Post. 2014-03-17. Retrieved 2015-01-07.
- Cite error: The named reference
Law360octwas invoked but never defined (see the help page). - Elaine Schmidt for UCLA News. July 29, 2013 Jules Stein Eye Institute at UCLA and Doheny Eye Institute pursue long-term affiliation
- Eye, Newsletter of the Stein Eye Institute, UCLA. Winter 2014. Stein and Doheny Eye Institute Sign Historic Affiliation Agreement
- "International expert in eye diseases returns to Keck School". USC News. 2014-11-14. Retrieved 2015-01-07.
{{cite web}}: Italic or bold markup not allowed in:|publisher=(help) - Eric Swanson for Optical Coherence Tomography News. Mar 29 2009 Ophthalmic Optical Coherence Tomography Market: Past, Present, & Future
- Jerry Helzner for Ophthalmology Management July 1 2012 Finding “Big Ideas” in Ophthalmic Innovation
- Huang lab website Accessed Feb 15, 2015
- Humayun faculty page at USC Keck Page accessed Feb 15 2015
- U.S. Department of Energy Office of Science. "Overview of the Artificial Retina Project".
- ^ Second SIght. Nov 14, 2014 [https://www.sec.gov/Archives/edgar/data/1266806/000161577414000310/s100457_s1a.htm Second Sight Amendment No. 3 to Form S-1: Registration Statement
- Miriam Karmel for Eyenet Magazine, March 2012 Clinical Update: Retina. Retinal Prostheses: Progress and Problems
- "Meet Dr. George Baerveldt". NVision. 2010-06-11. Retrieved 2015-01-10.
- "Clinical trial to study loss of vision". ResearchGate. 2013-12-16. Retrieved 2015-01-11.
- ^ "Top-Ranked Hospitals for Ophthalmology". U.S. News & World Report. 2014-07-15. Retrieved 2015-01-11.
{{cite web}}: Italic or bold markup not allowed in:|publisher=(help) - "Keck Medical Center of USC". U.S. News & World Report. Retrieved 2015-01-12.
{{cite web}}: Italic or bold markup not allowed in:|publisher=(help)