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Allisartan isoproxil: Difference between revisions

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| PubChem = 24748496 | PubChem = 24748496
| UNII = DI4662MK4N | UNII = DI4662MK4N
| ChemSpiderID = 57583156
| DrugBank = DB18880 | DrugBank = DB18880
<!-- Chemical and physical data --> <!-- Chemical and physical data -->

Latest revision as of 21:49, 7 January 2025

Pharmaceutical compound
Allisartan isoproxil
Identifiers
IUPAC name
  • Propan-2-yloxycarbonyloxymethyl 2-butyl-5-chloro-3-phenyl]methyl]imidazole-4-carboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
Chemical and physical data
FormulaC27H29ClN6O5
Molar mass553.02 g·mol
3D model (JSmol)
SMILES
  • CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCOC(=O)OC(C)C)Cl
InChI
  • InChI=1S/C27H29ClN6O5/c1-4-5-10-22-29-24(28)23(26(35)37-16-38-27(36)39-17(2)3)34(22)15-18-11-13-19(14-12-18)20-8-6-7-9-21(20)25-30-32-33-31-25/h6-9,11-14,17H,4-5,10,15-16H2,1-3H3,(H,30,31,32,33)
  • Key:XMHJQQAKXRUCHI-UHFFFAOYSA-N

Allisartan isoproxil is an antihypertensive pharmaceutical drug. It belongs to the angiotensin II receptor blocker class of drugs. It is an esterified prodrug, and its metabolism results in the formation of a single metabolite, losartan carboxylic acid (EXP3174), an oxidized form of losartan.

Chemical structure of losartan carboxylic acid

In China, allisartan isoproxil was approved by the Chinese Food and Drug Administration for the treatment of hypertension in 2012, and introduced to the market in 2013.

References

  1. Zhang JQ, Yang GH, Zhou X, Liu JX, Shi R, Dong Y, et al. (March 2019). "Effects of allisartan isoproxil on blood pressure and target organ injury in patients with mild to moderate essential hypertension". Medicine. 98 (12): e14907. doi:10.1097/MD.0000000000014907. PMC 6708765. PMID 30896643.
  2. ^ Zhao F, Liu Y, Chen L (2024). "Efficacy and safety evaluation of Allisartan Isoproxil in patients with hypertension: a meta-analysis". Frontiers in Cardiovascular Medicine. 11: 1355014. doi:10.3389/fcvm.2024.1355014. PMC 11187348. PMID 38903964.
  3. Wang H, Xi Y, Chen Y, Wang L, Yang F, Lu X, et al. (September 2023). "Efficacy of Allisartan Isoproxil in the Treatment of Mild-to-Moderate Essential Hypertension". American Journal of Hypertension. 36 (10): 561–567. doi:10.1093/ajh/hpad055. PMID 37343187.
  4. Ling QS, Zhang SL, Tian JS, Cheng MH, Liu AJ, Fu FH, et al. (June 2021). "Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage". Acta Pharmacologica Sinica. 42 (6): 871–884. doi:10.1038/s41401-021-00684-7. PMC 8149727. PMID 34002042.
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