Revision as of 01:28, 6 August 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (changes to verified fields - updated 'DrugBank_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacology|erro← Previous edit | Revision as of 19:24, 7 August 2011 edit undoCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChEBI_Ref', 'KEGG_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacology|errorsNext edit → | ||
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⚫ | | UNII_Ref = {{fdacite|correct|FDA}} | ||
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| UNII = 1Q8D39N37L | | UNII = 1Q8D39N37L | ||
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| verifiedrevid = 443275125 | ||
| IUPAC_name = 5-amino-2--1''H''-benzoisoquinoline-1,3(2''H'')-dione | | IUPAC_name = 5-amino-2--1''H''-benzoisoquinoline-1,3(2''H'')-dione | ||
| image = Amonafide.svg | | image = Amonafide.svg |
Revision as of 19:24, 7 August 2011
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Formula | C16H17N3O3 |
Molar mass | 283.325 g/mol g·mol |
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Amonafide (originally AS1413) (INN, trade name Quinamed) is a drug that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and DNA intercalators.
It is being developed as an anti-cancer therapy by Antisoma.
As of 2008, it is in Phase III clinical trials. eg In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).
References
- http://www.genengnews.com/news/bnitem.aspx?name=78979622
- http://clinicaltrials.gov/ct2/show/NCT00715637 "Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study"
External links
- Amonafide entry in the public domain NCI Dictionary of Cancer Terms
- Clinical trials of amonafide at ClinicalTrials.gov
This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.
This antineoplastic or immunomodulatory drug article is a stub. You can help Misplaced Pages by expanding it. |