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'''4-Fluoropethidine''' is a drug that is a derivative of ] (meperidine), which combines pethidine's ] ] effects with increased ] ]. It is around 50% less potent than pethidine as an opioid analgesic, but conversely is 50% more potent as a ], with other derivatives such as the 4-iodo and 3,4-dichloro analogues being even more potent dopamine reuptake inhibitors again. However none of these compounds substitute for ] or produce ] effects in animals, suggesting that they still act primarily as opioid analgesic drugs in practice.<ref name="pmid15743177">{{cite journal |author=Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML |title=Synthesis and biological evaluation of meperidine analogues at monoamine transporters |journal=Journal of Medicinal Chemistry |volume=48 |issue=5 |pages=1336–43 |year=2005 |month=March |pmid=15743177 |doi=10.1021/jm0401614 |url=}}</ref> |
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'''4-Fluoropethidine''' is a drug that is a derivative of ] (meperidine), which combines pethidine's ] ] effects with increased ] ]. It is around 50% less potent than pethidine as an opioid analgesic, but conversely is 50% more potent as a ], with other derivatives such as the 4-iodo and 3,4-dichloro analogues being even more potent dopamine reuptake inhibitors again. However none of these compounds substitute for ] or produce ] effects in animals, suggesting that they still act primarily as opioid analgesic drugs in practice.<ref name="pmid15743177">{{cite journal |author=Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML |title=Synthesis and biological evaluation of meperidine analogues at monoamine transporters |journal=Journal of Medicinal Chemistry |volume=48 |issue=5 |pages=1336–43 |date=March 2005 |pmid=15743177 |doi=10.1021/jm0401614 |url=}}</ref> |
