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'''FG-7142''' ('''ZK-31906''') is a drug which acts as a partial ] at the ] ] site of the ].<ref name="pmid17503486">{{cite journal |vauthors=Stevenson CW, Halliday DM, Marsden CA, Mason R |title=Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions |journal=Synapse |volume=61 |issue=8 |pages=646–63 |year=2007 |pmid=17503486 |doi=10.1002/syn.20414|citeseerx=10.1.1.323.5370 }}</ref> It has ],<ref>{{cite journal | vauthors = Cottone P, Sabino V, Steardo L, Zorrilla EP | date = May 2007 | title = FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability | journal = Neuropsychopharmacology | volume = 32 | issue = 5| pages = 1069–81 | pmid = 17077811 | doi = 10.1038/sj.npp.1301229 | doi-access = free }}</ref> ] and pro-] effects.<ref>{{cite journal | vauthors = Evans AK, Lowry CA | date = Winter 2007 | title = Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA<sub>A</sub> receptor: neurochemical, neurophysiological, and behavioral effects | journal = CNS Drug Reviews | volume = 13 | issue = 4 | pages = 475–501 | pmid = 18078430 | doi = 10.1111/j.1527-3458.2007.00025.x | doi-access = free | pmc = 6494137 }}</ref> It also increases release of ] and ],<ref>{{cite journal | vauthors = Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R | year = 2006 | title = Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat | journal = Neuroscience | volume = 141 | issue = 3| pages = 1481–8 | pmid = 16781820 | doi = 10.1016/j.neuroscience.2006.05.006 }}</ref> and improves memory retention in animal studies.<ref>{{cite journal | vauthors = McNally GP, Augustyn KA, Richardson R | year = 2008 | title = GABA<sub>A</sub> receptors determine the temporal dynamics of memory retention | journal = Learning and Memory | volume = 15 | issue = 3 | pages = 106–11 | pmid = 18285469 | doi = 10.1101/lm.806008 | doi-access = free | pmc = 2275652 }}</ref> |
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'''FG-7142''' ('''ZK-31906''') is a drug which acts as a partial ] at the ] ] site of the ].<ref name="pmid17503486">{{cite journal |vauthors=Stevenson CW, Halliday DM, Marsden CA, Mason R |title=Systemic administration of the benzodiazepine receptor partial inverse agonist FG-7142 disrupts corticolimbic network interactions |journal=Synapse |volume=61 |issue=8 |pages=646–63 |year=2007 |pmid=17503486 |doi=10.1002/syn.20414|citeseerx=10.1.1.323.5370 |s2cid=13415418 }}</ref> It has ],<ref>{{cite journal | vauthors = Cottone P, Sabino V, Steardo L, Zorrilla EP | date = May 2007 | title = FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability | journal = Neuropsychopharmacology | volume = 32 | issue = 5| pages = 1069–81 | pmid = 17077811 | doi = 10.1038/sj.npp.1301229 | doi-access = free }}</ref> ] and pro-] effects.<ref>{{cite journal | vauthors = Evans AK, Lowry CA | date = Winter 2007 | title = Pharmacology of the β-carboline FG-7142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA<sub>A</sub> receptor: neurochemical, neurophysiological, and behavioral effects | journal = CNS Drug Reviews | volume = 13 | issue = 4 | pages = 475–501 | pmid = 18078430 | doi = 10.1111/j.1527-3458.2007.00025.x | doi-access = free | pmc = 6494137 }}</ref> It also increases release of ] and ],<ref>{{cite journal | vauthors = Claustre Y, Rouquier L, Desvignes C, Leonetti M, Montégut J, Aubin N, Allouard N, Bougault I, Oury-Donat F, Steinberg R | year = 2006 | title = Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat | journal = Neuroscience | volume = 141 | issue = 3| pages = 1481–8 | pmid = 16781820 | doi = 10.1016/j.neuroscience.2006.05.006 | s2cid = 24944657 }}</ref> and improves memory retention in animal studies.<ref>{{cite journal | vauthors = McNally GP, Augustyn KA, Richardson R | year = 2008 | title = GABA<sub>A</sub> receptors determine the temporal dynamics of memory retention | journal = Learning and Memory | volume = 15 | issue = 3 | pages = 106–11 | pmid = 18285469 | doi = 10.1101/lm.806008 | doi-access = free | pmc = 2275652 }}</ref> |
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Infobox references
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