Revision as of 06:04, 26 November 2021 editCitation bot (talk | contribs)Bots5,461,100 edits Add: s2cid. | Use this bot. Report bugs. | Suggested by BrownHairedGirl | Linked from User:BrownHairedGirl/Articles_with_bare_links | #UCB_webform_linked 984/2164← Previous edit | Revision as of 02:27, 17 January 2022 edit undoRlink2 (talk | contribs)Extended confirmed users309,868 editsm →top: Filling completely bare references Misplaced Pages:Bare_URLsTag: AWBNext edit → | ||
Line 54: | Line 54: | ||
}} | }} | ||
'''Vindesine''', also termed Eldisine, is a ] ] derived from the flowering plant ''].''<ref name="pmid31228447">{{cite journal | vauthors = Mondal A, Gandhi A, Fimognari C, Atanasov AG, Bishayee A | title = Alkaloids for cancer prevention and therapy: Current progress and future perspectives | journal = European Journal of Pharmacology | volume = 858 | pages = 172472 | date = September 2019 | pmid = 31228447 | doi = 10.1016/j.ejphar.2019.172472 | s2cid = 195298770 }}</ref> Like the natural (e.g. ] and ]) and semisynthetic vinca alkaloids (e.g. ] and ]) derived from this plant, vindesine is an ] that is used as a ] drug.<ref name="pmid30122223">{{cite journal | vauthors = Martino E, Casamassima G, Castiglione S, Cellupica E, Pantalone S, Papagni F, Rui M, Siciliano AM, Collina S | title = Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead | journal = Bioorganic & Medicinal Chemistry Letters | volume = 28 | issue = 17 | pages = 2816–2826 | date = September 2018 | pmid = 30122223 | doi = 10.1016/j.bmcl.2018.06.044 | s2cid = 52039135 }}</ref> By inhibiting ], vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as ], ], ], ], and ].<ref>https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/vindesine</ref> | '''Vindesine''', also termed Eldisine, is a ] ] derived from the flowering plant ''].''<ref name="pmid31228447">{{cite journal | vauthors = Mondal A, Gandhi A, Fimognari C, Atanasov AG, Bishayee A | title = Alkaloids for cancer prevention and therapy: Current progress and future perspectives | journal = European Journal of Pharmacology | volume = 858 | pages = 172472 | date = September 2019 | pmid = 31228447 | doi = 10.1016/j.ejphar.2019.172472 | s2cid = 195298770 }}</ref> Like the natural (e.g. ] and ]) and semisynthetic vinca alkaloids (e.g. ] and ]) derived from this plant, vindesine is an ] that is used as a ] drug.<ref name="pmid30122223">{{cite journal | vauthors = Martino E, Casamassima G, Castiglione S, Cellupica E, Pantalone S, Papagni F, Rui M, Siciliano AM, Collina S | title = Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead | journal = Bioorganic & Medicinal Chemistry Letters | volume = 28 | issue = 17 | pages = 2816–2826 | date = September 2018 | pmid = 30122223 | doi = 10.1016/j.bmcl.2018.06.044 | s2cid = 52039135 }}</ref> By inhibiting ], vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as ], ], ], ], and ].<ref>{{cite web |url=https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/vindesine |title = Vindesine (Eldisine) {{!}} Cancer information {{!}} Cancer Research UK}}</ref> | ||
== References == | == References == |
Revision as of 02:27, 17 January 2022
Pharmaceutical compoundClinical data | |
---|---|
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Pregnancy category |
|
Routes of administration | Intravenous |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Protein binding | 65-75% |
Metabolism | Hepatic (CYP3A4-mediated) |
Elimination half-life | 24 hours |
Excretion | Biliary and renal |
Identifiers | |
IUPAC name
| |
CAS Number |
|
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII |
|
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.053.330 |
Chemical and physical data | |
Formula | C43H55N5O7 |
Molar mass | 753.941 g·mol |
3D model (JSmol) | |
SMILES
| |
InChI
| |
(verify) |
Vindesine, also termed Eldisine, is a semisynthetic vinca alkaloid derived from the flowering plant Catharanthus roseus. Like the natural (e.g. vinblastine and vincristine) and semisynthetic vinca alkaloids (e.g. vinorelbine and vinflunine) derived from this plant, vindesine is an inhibitor of mitosis that is used as a chemotherapy drug. By inhibiting mitosis, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as leukaemia, lymphoma, melanoma, breast cancer, and lung cancer.
References
- Mondal A, Gandhi A, Fimognari C, Atanasov AG, Bishayee A (September 2019). "Alkaloids for cancer prevention and therapy: Current progress and future perspectives". European Journal of Pharmacology. 858: 172472. doi:10.1016/j.ejphar.2019.172472. PMID 31228447. S2CID 195298770.
- Martino E, Casamassima G, Castiglione S, Cellupica E, Pantalone S, Papagni F, Rui M, Siciliano AM, Collina S (September 2018). "Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead". Bioorganic & Medicinal Chemistry Letters. 28 (17): 2816–2826. doi:10.1016/j.bmcl.2018.06.044. PMID 30122223. S2CID 52039135.
- "Vindesine (Eldisine) | Cancer information | Cancer Research UK".
This antineoplastic or immunomodulatory drug article is a stub. You can help Misplaced Pages by expanding it. |