| Revision as of 21:24, 12 July 2024 editRcfische2 (talk | contribs)123 edits Misplaced Pages should not be telling people to consult "Qualified healthcare professionals"← Previous edit |
Latest revision as of 21:25, 12 July 2024 edit undoRcfische2 (talk | contribs)123 edits Actually, this sounds better. |
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==Mechanism of action== |
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==Mechanism of action== |
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Acetohexamide bind to an ] (K<sub>ATP</sub>) channel on the cell membrane of ]s. This inhibits the out flux of ], which causes the ] to become more positive. This depolarization in turn opens ]s. The rise in intracellular ] leads to increased fusion of ] with the cell membrane, and therefore increased secretion of insulin.<ref>{{cite web | title = Acetohexamide | url = https://go.drugbank.com/drugs/DB00414 | work = DrugBank }}</ref> |
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Acetohexamide binds to an ] (K<sub>ATP</sub>) channel on the cell membrane of ]s. This inhibits the outflux of ], which causes the ] to become more positive. This depolarization in turn opens ]s. The rise in intracellular ] leads to increased fusion of ] with the cell membrane, and therefore increased secretion of insulin.<ref>{{cite web | title = Acetohexamide | url = https://go.drugbank.com/drugs/DB00414 | work = DrugBank }}</ref> |
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==Risks== |
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==Risks== |
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Oral hypoglycemic drugs, including acetohexamide, have been associated with increased ] mortality. <ref>{{cite web | title = Acetohexamide | url = https://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682478.html | work = Medline Plus | archive-url = https://web.archive.org/web/20050911024428/http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682478.html | archive-date = 11 September 2005 }}</ref> |
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Sulfonylureas, especially first-generation sulfonylureas such as Acetohexamide, can cause severe hypoglycemia and increase the risk of adverse cardiovascular events. <ref>{{cite web |url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/017532s030lbl.pdf |title=www.accessdata.fda.gov}}</ref><ref>{{cite web | title = Acetohexamide | url = https://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682478.html | work = Medline Plus | archive-url = https://web.archive.org/web/20050911024428/http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682478.html | archive-date = 11 September 2005 }}</ref> |
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==References== |
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==References== |
Sulfonylureas, especially first-generation sulfonylureas such as Acetohexamide, can cause severe hypoglycemia and increase the risk of adverse cardiovascular events.
