Imocitrelvir: Difference between revisions

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Pharmaceutical compound

Imocitrelvir
Clinical data

Other names	AG-7404, V-7404
Identifiers
IUPAC name ethyl (E,4S)-4--2-oxopyridin-1-yl]pent-4-ynoyl]amino]-5-pent-2-enoate
CAS Number	343565-99-1
PubChem CID	5280053
IUPHAR/BPS	13223
UNII	VQ1AN3OO42
ChEMBL	ChEMBL141157
Chemical and physical data
Formula	C₂₆H₂₉N₅O₇
Molar mass	523.546 g·mol
3D model (JSmol)	Interactive image
SMILES CCOC(=O)/C=C/(C1CCNC1=O)NC(=O)(CC#C)N2C=CC=C(C2=O)NC(=O)C3=NOC(=C3)C
InChI InChI=InChI=1S/C26H29N5O7/c1-4-7-21(31-13-6-8-19(26(31)36)29-24(34)20-14-16(3)38-30-20)25(35)28-18(9-10-22(32)37-5-2)15-17-11-12-27-23(17)33/h1,6,8-10,13-14,17-18,21H,5,7,11-12,15H2,2-3H3,(H,27,33)(H,28,35)(H,29,34)/b10-9+/t17-,18+,21-/m0/s1 Key:QCUZOJBYWQPLIN-BNMFZAHFSA-N

Imocitrelvir is an investigational new drug that is being evaluated for the treatment of viral infections. It is a 3C protease inhibitor in picornaviruses. Originally developed by Pfizer for treating human rhinovirus infections, this small molecule has shown promise against a broader range of viruses, including polioviruses.

References

"Imocitrelvir". PatSnap.
Xie H, Rhoden EE, Liu HM, Ogunsemowo F, Mainou BA, Burke RM, et al. (November 2024). "Antiviral Development for the Polio Endgame: Current Progress and Future Directions". Pathogens. 13 (11). Basel, Switzerland: 969. doi:10.3390/pathogens13110969. PMC 11597170. PMID 39599522.
Bandyopadhyay AS, Burke RM, Hawes KM (June 2024). "Polio Eradication: Status, Struggles and Strategies". The Pediatric Infectious Disease Journal. 43 (6): e207-211. doi:10.1097/INF.0000000000004330. PMID 38564755.

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