Fosdesdenosine sipalabenamide: Difference between revisions

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Pharmaceutical compound

Fosdesdenosine sipalabenamide
Clinical data

Other names	NUC-7738
Identifiers
IUPAC name benzyl (2S)-2-methoxy-phenoxyphosphoryl]amino]propanoate
CAS Number	2348493-39-8
PubChem CID	166177279
DrugBank	DB19148
UNII	Y7BFN2M72F
ChEMBL	ChEMBL5277528
Chemical and physical data
Formula	C₂₆H₂₉N₆O₇P
Molar mass	568.527 g·mol
3D model (JSmol)	Interactive image
SMILES C(C(=O)OCC1=CC=CC=C1)NP(=O)(OC2C((O2)N3C=NC4=C(N=CN=C43)N)O)OC5=CC=CC=C5
InChI InChI=InChI=1S/C26H29N6O7P/c1-17(26(34)36-13-18-8-4-2-5-9-18)31-40(35,39-19-10-6-3-7-11-19)37-14-20-12-21(33)25(38-20)32-16-30-22-23(27)28-15-29-24(22)32/h2-11,15-17,20-21,25,33H,12-14H2,1H3,(H,31,35)(H2,27,28,29)/t17-,20-,21+,25+,40?/m0/s1 Key:UDLWWGQHMQIYCV-LKKHFEEPSA-N

Fosdesdenosine sipalabenamide is an investigational new drug that is being evaluated for the treatment of advanced solid tumors and lymphoma. This compound is a phosphoramidate derivative of cordycepin (3'-deoxyadenosine), an adenosine analog originally isolated from the fungus Cordyceps. As a nucleoside analog with potential antineoplastic properties, Fosdesdenosine sipalabenamide is designed to inhibit RNA synthesis and act as an RNA inhibitor. The drug is being developed by NuCana Plc.

References

^ "Fosdesdenosine sipalabenamide". PatSnap.
"Fosdesdenosine Sipalabenamide". PubChem. U.S. National Library of Medicine.

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