Artemotil: Difference between revisions

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Revision as of 13:55, 28 October 2011 editBeetstra (talk \| contribs)Edit filter managers, Administrators172,084 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: '').← Previous edit		Revision as of 14:06, 28 October 2011 edit undoCheMoBot (talk \| contribs)Bots141,565 edits Updating {{drugbox}} (changes to verified fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'CAS_number_Ref') per [[WP:CHEMVALID\|Chem/Drugbox valid...Next edit →
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	{{Drugbox		{{Drugbox
			\| Verifiedfields = changed
			\| verifiedrevid = 457818666
	\| IUPAC_name = (5a''S'',6''R'',8a''S'',9''R'',10''S'',12''R'',12a''R'')-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxydioxepinoisochromene		\| IUPAC_name = (5a''S'',6''R'',8a''S'',9''R'',10''S'',12''R'',12a''R'')-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxydioxepinoisochromene
	\| image = Artemotil.svg		\| image = Artemotil.svg
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	<!--Identifiers-->		<!--Identifiers-->
			\| CAS_number_Ref = {{cascite\|changed\|??}}
	\| CAS_number = 75887-54-6		\| CAS_number = 75887-54-6
	\| ATC_prefix = P01		\| ATC_prefix = P01
	\| ATC_suffix = BE04		\| ATC_suffix = BE04
	\| PubChem = 72416		\| PubChem = 72416
			\| DrugBank_Ref = {{drugbankcite\|correct\|drugbank}}
	\| DrugBank =		\| DrugBank =
			\| ChemSpiderID_Ref = {{chemspidercite\|correct\|chemspider}}
	\| ChemSpiderID = 16735673		\| ChemSpiderID = 16735673
	\| UNII_Ref = {{fdacite\|correct\|FDA}}		\| UNII_Ref = {{fdacite\|correct\|FDA}}
	\| UNII = XGL7GFB9YI		\| UNII = XGL7GFB9YI
			\| ChEMBL_Ref = {{ebicite\|changed\|EBI}}
	\| ChEMBL = 301267		\| ChEMBL = 301267

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	\| InChI = 1/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17?/m1/s1		\| InChI = 1/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17?/m1/s1
	\| InChIKey = NLYNIRQVMRLPIQ-LCAQWSNOBS		\| InChIKey = NLYNIRQVMRLPIQ-LCAQWSNOBS
			\| StdInChI_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChI = 1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17?/m1/s1		\| StdInChI = 1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17?/m1/s1
			\| StdInChIKey_Ref = {{stdinchicite\|correct\|chemspider}}
	\| StdInChIKey = NLYNIRQVMRLPIQ-LCAQWSNOSA-N		\| StdInChIKey = NLYNIRQVMRLPIQ-LCAQWSNOSA-N
	}}		}}

Revision as of 14:06, 28 October 2011

Pharmaceutical compound

Artemotil
Clinical data

AHFS/Drugs.com	International Drug Names
Pregnancy category	not available
Routes of administration	Intramuscular injection
ATC code	P01BE04 (WHO)
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	20 hours
Identifiers
IUPAC name (5aS,6R,8aS,9R,10S,12R,12aR)-10-ethoxy-3,6,9-trimethyldecahydro-3,12-epoxydioxepinoisochromene
CAS Number	75887-54-6
PubChem CID	72416
ChemSpider	16735673
UNII	XGL7GFB9YI
ChEMBL	ChEMBL301267
Chemical and physical data
Formula	C₁₇H₂₈O₅
Molar mass	312.401 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES C1CC3C42OO(C)(CC12)O4O(OCC)3C
InChI InChI=1S/C17H28O5/c1-5-18-14-11(3)13-7-6-10(2)12-8-9-16(4)20-15(19-14)17(12,13)22-21-16/h10-15H,5-9H2,1-4H3/t10-,11-,12+,13+,14+,15-,16-,17?/m1/s1 Key:NLYNIRQVMRLPIQ-LCAQWSNOSA-N
(what is this?) (verify)

Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua. It is currently only used as a second line drug in severe cases of malaria.

Antiparasitics – antiprotozoal agents – Chromalveolata antiparasitics (P01)

Alveo-
late

Apicom-
plexa

Conoidasida/
(Coccidiostats)

Cryptosporidiosis	thiazolides (nitazoxanide)
Isosporiasis	trimethoprim/sulfamethoxazole
Toxoplasmosis	pyrimethamine sulfadiazine clindamycin atovaquone

Individual
agents

4-Methanolquinolines

Other

lumefantrine
- + artemether

halofantrine

Antifolates

DHFR inhibitors

biguanides
- chlorproguanil
- proguanil

Sulfonamides

Co-formulation

sulfadoxine/pyrimethamine (SP)

Sesquiterpene
lactones

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine piperaquine/dihydroartemisinin
Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline

Babesiosis

clindamycin

Cilio-
phora

Balantidiasis: tetracycline

Stramen-
opile

Blastocystosis: metronidazole

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

This antiinfective drug article is a stub. You can help Misplaced Pages by expanding it.

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