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Revision as of 19:30, 29 July 2020

Ideal sources for Misplaced Pages's health content are defined in the guideline Misplaced Pages:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Alzheimer's disease. PubMed provides review articles from the past five years (limit to free review articles) The TRIP database provides clinical publications about evidence-based medicine. Other potential sources include: Centre for Reviews and Dissemination and CDC

This is the talk page for discussing improvements to the Alzheimer's disease article. This is not a forum for general discussion of the article's subject.

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	Alzheimer's disease is a featured article; it (or a previous version of it) has been identified as one of the best articles produced by the Misplaced Pages community. Even so, if you can update or improve it, please do so.
[REDACTED]	This article appeared on Misplaced Pages's Main Page as Today's featured article on September 21, 2008.
Article milestones Date Process Result July 3, 2006 Good article nominee Listed October 14, 2006 Peer review Reviewed June 12, 2008 Featured article candidate Not promoted August 25, 2008 Featured article candidate Promoted A news item involving this article was featured on Misplaced Pages's Main Page in the "In the news" column on August 10, 2010. Current status: Featured article

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This article is written in British English, which has its own spelling conventions (colour, travelled, centre, defence, artefact, analyse) and some terms that are used in it may be different or absent from other varieties of English. According to the relevant style guide, this should not be changed without broad consensus.

The contents of the Retrogenesis page were merged into Alzheimer's disease. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page.

Revisions succeeding this version of this article is substantially duplicated by a piece in an external publication. Since the external publication copied Misplaced Pages rather than the reverse, please do not flag this article as a copyright violation of the following source: Alzheimer’s Disease: A Review (PDF), Scientia Ricerca, March 3, 2018 Additional comments See Talk:Dementia with Lewy bodies/Alain L. Fymat

Semi-protected edit request on 17 May 2020 : Blood Brain Barrier

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Recently there has been a very important Nature publication in Alzheimer research:

- paper: https://www.nature.com/articles/s41586-020-2247-3

- nature coverage: https://www.nature.com/articles/d41586-020-01152-8

The paper gives much more credit to the blood brain barrier damage hypothesis in the contest of APOE4 mutation. I think it would be worth it to add a whole paragraph beneath the "causes" or a subparagraph beneath the "genetic causes" as this remarkable paper goes into great depth describing the effect of APOE4 mutation , how the blood brain barrier leaks, how pericite with APOE4 mutation are dysfunctional secreting more cyclophilin A (CypA) and matrix metalloproteinase-9 (MMP9) causing the damage and demise of nearby pericites, and especially how all this is independent of Aβ and tau accumulation.

Suggested change with a paragraph in Causes (sorry i don't know the needed formatting to make it):

Blood brain barrier damage:

A neurovascular hypothesis has been proposed which states that poor functioning of the blood–brain barrier may be involved.. It has been found that the blood–brain barrier (BBB) breakdown may be an early biomarker of human cognitive dysfunction , as individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer’s Aβ and/or tau biomarker changes. This has been proven in the setting of APOE4 mutated patients where cognitively unimpaired APOE4 carriers already show signs of the breakdown of the BBB in the hippocampus and medial temporal lobe, more severily in those with cognitive impairment, without the fingding being related to amyloid-β or tau pathology. The biomarker of pericyte injury, soluble PDGFRβ ,, in the cerebrospinal fluid predicted future cognitive decline in APOE4 carriers but not in non-carriers. Apparently this damage is driven by dysfunctional APOE4 mutated pericites , which produce more cyclophilin A (CypA) and matrix metalloproteinase-9 (MMP9) causing the damage and demise of nearby pericites. Alessandro313 (talk) 07:16, 17 May 2020 (UTC)

References

1. https://www.nature.com/articles/s41591-018-0297-y
2. https://www.nature.com/articles/s41586-020-2247-3
3. https://www.cell.com/neuron/fulltext/S0896-6273(14)01141-6
4. https://www.nature.com/articles/s41591-018-0297-y

@Alessandro313: The authors of the three articles have been doing research on BBB for over five years now. While the results are interesting, they are still only primary sources, and we really would prefer a good secondary source that reviews the field and forms some conclusions about the relative importance of the blood–brain barrier. That would be needed to expand the Causes section. Instead, I suggest that a brief summary in the Research directions - Diagnosis section would be appropriate until secondary sources report on the studies. I've added a sentence and the three sources at the end of the section. --RexxS (talk) 23:34, 4 June 2020 (UTC)

Blood test

It was announced on the BBC Radio Four news this morning (Wednesday 29 July 2020) that a blood test could detect whether people are at risk of Alzheimer's twenty years before they show symptoms. I am sure I heard on the "What the Papers Say" section that the Daily Telegraph talks about this. If any one knows about this and can provide reliable sources, it could be added to the article. This would help Misplaced Pages to be an up-to-date encyclopedia. 06:15, 29 July 2020 (UTC)

Thanks for the suggestion. If you can find the medical study source and it meets WP:MEDRS (e.g., is it also shared in a high-quality review article or a systematic review) then I can help add this information. Great to have so many people helping to keep the articles up to date! JenOttawa (talk) 16:34, 29 July 2020 (UTC)

FAR needed

This is a 2008 Featured article that averages 3,000 daily pageviews whose main writers have not edited since 2012 (OrangeMarlin) and 2013 (Garrondo). It has fallen out of standard and will need to be sent to WP:FAR unless someone takes on the issues, including a comprehensive update. Wherever one glances there are issues:

• The Further reading section contains only dated entries. FAs are supposed to be comprehensive, so items listed there need explanation.
• A consistent citation style (the Boghog/Diberri format with vancouver-style authors) has not been maintained.
• The WHO and NIH sources have been considerably used, rather than sourcing to the more authoritative, underlying published literature.
• Many of the sources used are considerably dated-- it does not seem that the article has been routinely updated to newer sources, or is sourced to the highest standards per WP:WIAFA and WP:MEDDATE.
• The Research directions section is particularly problematic, and has become a catch-all (which may work for most articles, but not for the high standards required of a Featured article). That section is using lay sources and has very dated sources as well ... if something in research is significant, it will eventually be mentioned in a secondary review. The Research directions section needs a complete rewrite, using the latest high quality secondary reviews, rather than a catch-all reflecting the popular press.
• The considerable overlap between Dementia with Lewy bodies and Alzheimer's is not developed, with one passing sentence.
• There is a graph of deaths in ... 2012!
• Epidemiology has very dated sources.
• Sourced to 2008! Huperzine A while promising, requires further evidence before its use can be recommended.
• Sourced to 2010! The oldest hypothesis, on which most currently available drug therapies are based, is the cholinergic hypothesis, which proposes that AD is caused by reduced synthesis of the neurotransmitter acetylcholine. The cholinergic hypothesis has not maintained widespread support, largely because medications intended to treat acetylcholine deficiency have not been very effective. Either this hypothesis panned out, or it didn't. If it did, new source. If it didn't, remove, UNDUE. This is similar to what is found throughout the article, which is grossly outdated and needing a comprehensive rewrite.
• The lead has not been kept in sync with the body of the article-- there is information in the lead which is nowhere to be found in the article.
• This statement in the lead doesn't even belong in this article ... it is not about AZ, rather all dementia. In 2015, dementia resulted in about 1.9 million deaths.
• Sourced to 1998 and 2005!! In developed countries, AD is one of the most financially costly diseases.
• There are 2,000 reviews in the last year alone listed for Alzheimer's, yet the article stagnates.
• The spoken Misplaced Pages link is 12 years old ... should be removed from article and placed on talk.

I will put this forward to FAR in about a month unless someone is able to rewrite and update. The list above is samples only-- a top-to-bottom rewrite and update is needed, and SandyGeorgia (Talk) 19:30, 29 July 2020 (UTC)

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