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Cefpodoxime

Clinical data
Pregnancy category	AU: B1
Routes of administration	Oral
ATC code	J01DD13 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	50%
Protein binding	21% to 29%
Metabolism	Negligible. Cefpodoxime proxetil is metabolized to cefpodoxime by the liver
Elimination half-life	2 hours
Excretion	Renal, unchanged
Identifiers
IUPAC name (6R,7R)-7-{amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclooct-2-ene-2-carboxylic acid
CAS Number	82619-04-3
PubChem CID	6335986
ChemSpider	4891496
KEGG	D07650
ChEMBL	ChEMBL1672
CompTox Dashboard (EPA)	DTXSID6022765
ECHA InfoCard	100.210.871
Chemical and physical data
Formula	C15H17N5O6S2
Molar mass	427.458 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O=C2N1/C(=C(\CS12NC(=O)C(=N\OC)/c3nc(sc3)N)COC)C(=O)O
InChI InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1 Key:WYUSVOMTXWRGEK-HBWVYFAYSA-N
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Cefpodoxime is an oral third generation cephalosporin antibiotic. It is marketed as the prodrug cefpodoxime proxetil by Pharmacia & Upjohn under the trade name Vantin and under the name Orelox by ; PECEF in Dr Reddy's (Farhaad)]. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Pfizer, the parent company of Pharmacia & Upjohn, markets cefpodoxime proxetil under the trade name Simplicef for veterinary use. The dose range in dogs is 5–10 mg/kg body weight, administered orally, once a day.

External links

• CID 6526396 from PubChem - cefpodoxime proxetil
• Vantin Tablets and Oral Suspension Torpod (Torrent)Full U.S. Prescribing Information (from manufacturer's website)
• Simplicef (from manufacturer's website)

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