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Imocitrelvir

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Pharmaceutical compound
Imocitrelvir
Clinical data
Other namesAG-7404, V-7404
Identifiers
IUPAC name
  • ethyl (E,4S)-4--2-oxopyridin-1-yl]pent-4-ynoyl]amino]-5-pent-2-enoate
CAS Number
PubChem CID
IUPHAR/BPS
UNII
ChEMBL
Chemical and physical data
FormulaC26H29N5O7
Molar mass523.546 g·mol
3D model (JSmol)
SMILES
  • CCOC(=O)/C=C/(C1CCNC1=O)NC(=O)(CC#C)N2C=CC=C(C2=O)NC(=O)C3=NOC(=C3)C
InChI
  • InChI=InChI=1S/C26H29N5O7/c1-4-7-21(31-13-6-8-19(26(31)36)29-24(34)20-14-16(3)38-30-20)25(35)28-18(9-10-22(32)37-5-2)15-17-11-12-27-23(17)33/h1,6,8-10,13-14,17-18,21H,5,7,11-12,15H2,2-3H3,(H,27,33)(H,28,35)(H,29,34)/b10-9+/t17-,18+,21-/m0/s1
  • Key:QCUZOJBYWQPLIN-BNMFZAHFSA-N

Imocitrelvir is an investigational new drug that is being evaluated for the treatment of viral infections. It is a 3C protease inhibitor in picornaviruses. Originally developed by Pfizer for treating human rhinovirus infections, this small molecule has shown promise against a broader range of viruses, including polioviruses.

References

  1. "Imocitrelvir". PatSnap.
  2. Xie H, Rhoden EE, Liu HM, Ogunsemowo F, Mainou BA, Burke RM, et al. (November 2024). "Antiviral Development for the Polio Endgame: Current Progress and Future Directions". Pathogens. 13 (11). Basel, Switzerland: 969. doi:10.3390/pathogens13110969. PMC 11597170. PMID 39599522.
  3. Bandyopadhyay AS, Burke RM, Hawes KM (June 2024). "Polio Eradication: Status, Struggles and Strategies". The Pediatric Infectious Disease Journal. 43 (6): e207-211. doi:10.1097/INF.0000000000004330. PMID 38564755.
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