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Stefan Bräse is a German chemist and an academic. He is a Director of the Institute of Biological and Chemical Systems, Co-Director of the Soft Matter Synthesis Lab and a Full Professor at Karlsruhe Institute of Technology.

Bräse's research focuses on asymmetric synthesis, innovative combinatorial chemistry methods for biologically active compounds and catalysis, natural product synthesis on solid supports, including THC and Secalonic Acids, and functionalized nanostructures. His works have been published in academic journals, including Advanced Materials and Angewandte Chemie International Edition. Moreover, he received the 2019 Aspire Award with Nicole Jung and R. Bach.

Education and career

Bräse completed his chemistry studies at Georg-August-Universität Göttingen, Germany, and University College of North Wales, Bangor, United Kingdom, in 1992. He obtained his Habilitation from RWTH Aachen University in 2001. From 2001 to 2003, he was a Professor at the University of Bonn. In 2003, he was appointed Head of the Department of Organic Chemistry (Institut für Organische Chemie) at Universität Karlsruhe. Between 2004 and 2007, he held the position of Vertrauensdozent for Lehramt Chemie at Universität Karlsruhe. In 2007, he joined Karlsruhe Institute of Technology (KIT), where he has held various positions. From 2007 to 2012, he also held the role of Trust Professor of the Deutsche Forschungsgemeinschaft (DFG) at KIT. Between 2012 and 2019, he was the Director of the Institute of Toxicology and Genetics at KIT and the Managing Director of Heika, a research alliance between Heidelberg University and KIT, from 2012 to 2016. He has been a Full Professor at KIT since 2003.

Research

Bräse's research contributions span different areas of chemistry. His early work focused on synthetic organic chemistry, particularly the development of novel reaction methodologies. In 1996, he detailed a domino Heck-Diels-Alder reaction, enabling the synthesis of bicyclononenes and bicyclodecenes with high efficiency. This work introduced intramolecular Heck reactions involving bromomethylene cyclopropane systems without ring-opening, thereby expanding the boundaries of cyclopropane chemistry. Three years later, he explored the chemistry and biology of glycopeptide antibiotics, emphasizing their critical role in combating drug-resistant bacteria and the need for deeper insights to develop novel antibiotics. In subsequent years, his work broadened to include azide chemistry. In 2005, he reviewed the synthetic utility of organic azides, underlining their central role in cycloaddition reactions, heterocycle synthesis, and applications across chemistry, biology, and material sciences.

Bräse also made contributions to amino acid synthesis. A 2007 review analyzed advancements in the asymmetric synthesis of α,α-disubstituted α-amino acids. The oxa-Michael reaction was another focus of his research. In 2008, he detailed advancements that improved the reaction's reactivity and selectivity.

From 2010 onward, Bräse's work included material sciences and applied chemistry. He explored porous polymer networks (PPNs) for gas storage and separation, emphasizing their potential for clean energy applications. In 2012, his synthesis of luminescent dinuclear copper(I) complexes demonstrated their potential in OLED technology, with tunable photoluminescence and high quantum yields. One of his reviews, published in 2018 emphasized alternatives to iridium-based emitters, focusing on sustainable copper and zinc complexes, while a 2021 publication documented the evolution of OLED technologies, from fluorescence to advanced delayed fluorescence emitters. In 2023, he examined the chemistry of photochemically activated 3D printing inks, assessing the advancements and challenges in designing high-efficiency photoresists.

Awards and honors

• 1995 – Richard-Zsigmondy prize, Deutsche Kolloid-Gesellschaft
• 2000 – ORCHEM Prize for Natural Scientists, Gesellschaft Deutscher Chemiker
• 2019 – Aspire Award

Bibliography

Books

• Organic Azides: Syntheses and Applications (2009) ISBN 9780470519981
• Asymmetric Synthesis II: More Methods and Applications (2013) ISBN 9783527672592
• Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation (2015) ISBN 9781782620303

Selected articles

• Nicolaou, K. C., Boddy, C. N., Bräse, S., & Winssinger, N. (1999). Chemistry, biology, and medicine of the glycopeptide antibiotics. Angewandte Chemie International Edition, 38(15), 2096-2152.
• Bräse, S., Gil, C., Knepper, K., & Zimmermann, V. (2005). Organic azides: an exploding diversity of a unique class of compounds. Angewandte Chemie International Edition, 44(33), 5188-5240.
• Nising, C. F., & Bräse, S. (2008). The oxa-Michael reaction: from recent developments to applications in natural product synthesis. Chemical Society Reviews, 37(6), 1218-1228.
• Nising, C. F., & Bräse, S. (2012). Recent developments in the field of oxa-Michael reactions. Chemical Society Reviews, 41(3), 988-999.
• Hong, G., Gan, X., Leonhardt, C., Zhang, Z., Seibert, J., Busch, J. M., & Bräse, S. (2021). A brief history of OLEDs—emitter development and industry milestones. Advanced Materials, 33(9), 2005630.

References

1. ^ "Stefan Bräse - Google Schoalr".
2. ^ "NCATS ASPIRE Design Challenges Winners".
3. "Versatile synthesis of bicyclo[4.3.0]nonenes and bicyclo[4.4.0]decenes by a domino Heck-Diels-Alder reaction".
4. "Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics".
5. "Organic Azides: An Exploding Diversity of a Unique Class of Compounds".
6. "Recent approaches towards the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids".
7. "The oxa-Michael reaction: from recent developments to applications in natural product synthesis".
8. "Porous Polymer Networks: Synthesis, Porosity, and Applications in Gas Storage/Separation".
9. "Synthesis, Structure, and Characterization of Dinuclear Copper(I) Halide Complexes with P^N Ligands Featuring Exciting Photoluminescence Properties".
10. "Sustainable metal complexes for organic light-emitting diodes (OLEDs)".
11. "A Brief History of OLEDs—Emitter Development and Industry Milestones".
12. "Photochemically Activated 3D Printing Inks: Current Status, Challenges, and Opportunities".
13. "ORCHEM Prize for Young Scientists".

• German engineers
• German academics
• University of Göttingen alumni
• Alumni of Bangor University
• Academic staff of the Karlsruhe Institute of Technology
• Living people