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Axelrod or Akselrod is a surname and may refer to:

• Daniel I. Axelrod, an American paleoecologist, botanist, and geologist, known by the author abbreviation "Axelrod"
• David Axelrod (musician) (b. 1936), an American classical musician known for use of drums and incorporation of different styles
• David Axelrod (political consultant), a political consultant who has worked on campaigns of Barack Obama and Richard M. Daley
• David B. Axelrod (b. 1943), an American award-winning poet and educator
• George Axelrod (1922–2003), an American screenwriter, producer, playwright and film director
• Herbert R. Axelrod (Dr.) (b. 1927), an ichthyologist currently in prison for tax evasion
• Jason David Axelrod AKA David Ha'ivri (b. 1967) Jewish-Israeli settler activist and spokesman
• Julius Axelrod (1912–2004), an American biochemist who won a share of the Nobel Prize in Physiology or Medicine in 1970
• Lyubov' Akselrod (1868-1946), a Russian Marxist philosopher and revolutionary
• Meer Akselrod (1902-1970), a Russian painter known for his paintings of Jewish life in the Russian Empire and the Soviet Union
• Paul Axelrod (b. 1941), an author and a professor and dean at York University
• Pavel Akselrod (1850-1928), also spelled Pavel Axelrod, a Russian Menshevik revolutionary
• Robert Axelrod, an American professor of political science at the University of Michigan who has written about the evolution of cooperation
• Robert Axelrod (actor) (b. 1949), an American actor who has been in many movies and TV shows, often as a voice actor

• Surnames