Nitrofurazone - Misplaced Pages

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Revision as of 04:44, 21 October 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to verified fields - updated 'ChEBI_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs))(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound

Nitrofurazone
Clinical data

AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	B05CA03 (WHO) D08AF01 (WHO) D09AA03 (WHO) P01CC02 (WHO) S01AX04 (WHO) S02AA02 (WHO) QG01AX90 (WHO) QP51AC02 (WHO)
Identifiers
IUPAC name 5-nitro-2-furaldehyde semicarbazone
CAS Number	59-87-0
PubChem CID	5447130
DrugBank	DB00336
ChemSpider	4566720
UNII	X8XI70B5Z6
KEGG	C08042
ChEMBL	ChEMBL869
CompTox Dashboard (EPA)	DTXSID5020944
ECHA InfoCard	100.000.403
Chemical and physical data
Formula	C₆H₆N₄O₄
Molar mass	198.14 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES O=()c1oc(/C=N/NC(=O)N)cc1
InChI InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+ Key:IAIWVQXQOWNYOU-FPYGCLRLSA-N
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Nitrofurazone, 2-((5-nitro-2-furanyl)methylene)hydrazinecarboxamide, chemical formula C₆H₆N₄O₄, is a pale yellow crystalline compound.

This bactericidal compound is used as an antibiotic most commonly in the form of ointments. Its use in medicine has become less frequent as safer and more effective products have become available.

Other names for this chemical include nitrofural' and furacilin.

Synthesis

Stillman, W. B.; Scott, A. B.; 1947, U.S. patent 241,664.

Antiparasitics – antiprotozoal agents – Chromalveolata antiparasitics (P01)

Alveo-
late

Apicom-
plexa

Conoidasida/
(Coccidiostats)

Cryptosporidiosis	thiazolides (nitazoxanide)
Isosporiasis	trimethoprim/sulfamethoxazole
Toxoplasmosis	pyrimethamine sulfadiazine clindamycin atovaquone

Individual
agents

4-Methanolquinolines

Other

lumefantrine
- + artemether

halofantrine

Antifolates

DHFR inhibitors

biguanides
- chlorproguanil
- proguanil

Sulfonamides

Co-formulation

sulfadoxine/pyrimethamine (SP)

Sesquiterpene
lactones

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine piperaquine/dihydroartemisinin
Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline

Babesiosis

clindamycin

Cilio-
phora

Balantidiasis: tetracycline

Stramen-
opile

Blastocystosis: metronidazole

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

v t e Drugs used for diseases of the ear (S02)
Infection	Acetic acid Aluminium acetotartrate Aluminium triacetate (Burow's solution) Boric acid Chloramphenicol Chlorhexidine Ciprofloxacin Clioquinol Gentamicin Hydrogen peroxide Miconazole Neomycin Nitrofurazone Ofloxacin Polymyxin B Rifamycin Tetracycline
Corticosteroids	Betamethasone Dexamethasone Fluocinolone acetonide Hydrocortisone Prednisolone
Analgesics and anesthetics	Lidocaine Cocaine Phenazone

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