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Revision as of 12:37, 27 October 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to verified fields - updated 'ChEBI_Ref', 'KEGG_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report errors or bugs))(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound | |
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| AHFS/Drugs.com | Consumer Drug Information |
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| Routes of administration | Intravenous |
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| Pharmacokinetic data | |
| Bioavailability | NA |
| Protein binding | ~90% |
| Elimination half-life | 21.5 days (mean) |
| Excretion | Fecal |
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| Chemical and physical data | |
| Formula | C68H74N8O11 (for n=0) |
| Molar mass | Expression error: Unexpected < operator1179.36 g/mol (for n=0)Expression error: Unexpected < operator |
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Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.
Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units. In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.
Approvals and indications
It was approved in Canada in 1993 for the treatment of bladder cancer. It was approved in Japan in 1994 (for early stage lung cancer?). It was approved by the U.S. FDA in December 1995 esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer.
In August 2003 the FDA approved its use for Barrett's esophagus.
References
- http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020451s019lbl.pdf
- ^ http://journals.lww.com/jto/Fulltext/2006/06000/Photodynamic_Therapy__PDT__for_Lung_Cancers.18.aspx "Photodynamic Therapy (PDT) for Lung Cancers" 2006
- "FDA Patient Safety News: Show #20, October 2003". October 2003. Retrieved 2009-08-17.
External links
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