| Revision as of 13:03, 24 October 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,074 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEBI', 'StdInChI', 'StdInChIKey', 'ChEMBL').← Previous edit |
Latest revision as of 00:21, 14 January 2025 edit undoArthurfragoso (talk | contribs)Extended confirmed users, Template editors4,591 edits dark mode fix |
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{{Short description|Chemical compound}} |
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{{Drugbox |
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{{Infobox drug |
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| verifiedrevid = 457140599 |
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| Watchedfields = changed |
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| type = <!-- empty --> |
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| verifiedrevid = 402936607 |
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| IUPAC_name = ''N''-amino]ethyl] phenyl]formamide |
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| image = Arformoterol.svg |
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| image = Arformoterol.svg |
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| image_class = skin-invert-image |
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| width = 250 |
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| alt = |
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| image2 = Arformoterol ball-and-stick model.png |
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| width2 = |
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| alt2 = |
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| caption = |
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| USAN = Arformoterol tartrate |
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<!--Clinical data--> |
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<!-- Clinical data --> |
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| tradename = |
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| pronounce = |
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| tradename = Brovana |
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| Drugs.com = {{drugs.com|monograph|arformoterol-tartrate}} |
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| Drugs.com = {{drugs.com|monograph|arformoterol}} |
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| MedlinePlus = a602023 |
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| MedlinePlus = a602023 |
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| licence_US = Arformoterol |
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| DailyMedID = Arformoterol |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_AU_comment = |
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| pregnancy_US = C |
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| pregnancy_category= |
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| legal_AU = <!-- Unscheduled / S2 / S4 / S8 --> |
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| routes_of_administration = ] |
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| legal_UK = <!-- GSL / P / POM / CD --> |
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| class = |
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| legal_US = Rx-only |
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| ATCvet = |
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| routes_of_administration = ] |
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| ATC_prefix = None |
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| ATC_suffix = |
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| ATC_supplemental = |
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<!--Pharmacokinetic data--> |
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<!-- Legal status --> |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled --> |
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| legal_AU_comment = |
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| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F --> |
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| legal_BR_comment = |
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| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA_comment = |
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| legal_DE = <!-- Anlage I, II, III or Unscheduled --> |
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| legal_DE_comment = |
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| legal_NZ = <!-- Class A, B, C --> |
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| legal_NZ_comment = |
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| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C --> |
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| legal_UK_comment = |
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| legal_US = Rx-only |
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| legal_US_comment = <ref name="Brovana FDA label">{{cite web | title=Brovana- arformoterol tartrate solution | website=DailyMed | date=13 May 2021 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7134ae7c-6c64-470d-ab4e-81e35413b839 | access-date=4 March 2022}}</ref> |
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| legal_EU = |
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| legal_EU_comment = |
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| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV --> |
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| legal_UN_comment = |
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| legal_status = <!-- For countries not listed above --> |
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<!-- Pharmacokinetic data --> |
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| bioavailability = |
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| protein_bound = 52–65% |
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| protein_bound = 52–65% |
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| metabolism = |
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| metabolites = |
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| onset = |
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| elimination_half-life = 26 hours |
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| elimination_half-life = 26 hours |
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| duration_of_action = |
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| excretion = |
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<!--Identifiers--> |
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<!-- Identifiers --> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 67346-49-0 |
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| CAS_number = 67346-49-0 |
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| CAS_supplemental = |
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| ATC_prefix = none |
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| ChEBI = 408174 |
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| StdInChI = 1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1 |
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| StdInChIKey = BPZSYCZIITTYBL-YJYMSZOUSA-N |
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| PubChem = 3083544 |
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| PubChem = 3083544 |
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| IUPHAR_ligand = 7479 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB01274 |
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| DrugBank = DB01274 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 2340731 |
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| ChemSpiderID = 2340731 |
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| UNII_Ref = {{fdacite|changed|FDA}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = F91H02EBWT |
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| UNII = F91H02EBWT |
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| KEGG = D07463 |
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| KEGG2 = D02981 |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 408174 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEMBL = 1363 |
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| ChEMBL = 1201137 |
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| NIAID_ChemDB = |
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| PDB_ligand = |
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| synonyms = |
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<!-- Chemical and physical data --> |
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| IUPAC_name = ''N''-amino]ethyl] phenyl]formamide |
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| C=19 | H=24 | N=2 | O=4 |
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| C=19 | H=24 | N=2 | O=4 |
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| SMILES = |
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| molecular_weight = 344.405 g/mol |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1 |
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| StdInChI_comment = |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = BPZSYCZIITTYBL-YJYMSZOUSA-N |
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| density = |
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| density_notes = |
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| melting_point = |
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| melting_high = |
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| melting_notes = |
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| boiling_point = |
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| boiling_notes = |
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| solubility = |
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| sol_units = |
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| specific_rotation = |
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}} |
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}} |
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'''Arformoterol''' is a ] drug indicated for the treatment of ] (COPD). It is sold by ], under the trade name '''Brovana''', as a solution of arformoterol tartrate to be administered twice daily (morning and evening) by ].<ref>{{cite web |url=http://www.rxlist.com/cgi/generic/brovana_ids.htm |title=Brovana Prescribing information, Dosage and Administration section |accessdate=2008-03-14 |work= }}</ref> |
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'''Arformoterol''', sold under the brand name '''Brovana''' among others, is a ] used for the treatment of ] (COPD).<ref name="Brovana FDA label" /><ref name="Loh_2015">{{cite journal | vauthors = Loh CH, Donohue JF, Ohar JA | title = Review of drug safety and efficacy of arformoterol in chronic obstructive pulmonary disease | journal = Expert Opinion on Drug Safety | volume = 14 | issue = 3 | pages = 463–72 | date = March 2015 | pmid = 25563342 | doi = 10.1517/14740338.2015.998196 | s2cid = 7767810 }}</ref> |
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It is the active (R,R)-] of ] and was approved by the ] ] (FDA) on October 6, 2006 for the treatment of COPD. |
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It is a ] (LABA) and it is the active (''R'',''R'')-(−)-] of ].<ref name="Brovana FDA label" /> It was approved for medical use in the United States in October 2006.<ref name="Brovana FDA label" /> It is available as a ].<ref>{{cite web | title=Competitive Generic Therapy Approvals | website=U.S. ] (FDA) | date=29 June 2023 | url=https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals | access-date=29 June 2023 | archive-date=29 June 2023 | archive-url=https://web.archive.org/web/20230629233651/https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals | url-status=live }}</ref> |
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== Medical uses == |
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Arformoterol is ] for the maintenance treatment of bronchoconstriction in people with chronic obstructive pulmonary disease (COPD).<ref name="Brovana FDA label" /> |
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==References== |
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==References== |
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{{Reflist}} |
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{{Reflist}} |
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==External links== |
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== External links == |
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* {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/arformoterol | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Arformoterol }} |
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* website |
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* {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/arformoterol%20tartrate | publisher = U.S. National Library of Medicine | work = Drug Information Portal | title = Arformoterol tartrate }} |
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{{Adrenergic agonists}} |
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{{Asthma and copd rx}} |
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{{Asthma and copd rx}} |
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{{Adrenergic agonists}} |
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{{Portal bar | Medicine}} |
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