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Revision as of 10:07, 29 July 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,074 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: ChEMBL.← Previous edit		Latest revision as of 02:57, 26 October 2024 edit undo76.174.0.57 (talk) Cats.
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			{{Short description|Pharmaceutical drug}}
	{{Unreferenced stub|auto=yes|date=December 2009}}
	{{Merge|Methylscopolamine|date=October 2009}}
	{{Drugbox		{{Drugbox
		⚫	| verifiedrevid = 442016426
	| Verifiedfields = changed
		⚫	| IUPAC_name = (1''R'',2''S'',4''R'',5''S'',7''R''<nowiki>)-{oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclononane
⚫	| verifiedrevid = 402390676
		⚫	| image = Methscopolamine.png
⚫	| IUPAC_name = (1''R'',2''S'',4''R'',5''S'',7''R'')-{oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclononane
			<!--Clinical data-->| tradename = Pamine, Extendryl, AlleRx, Rescon
⚫	| image = Methscopolamine.png
			| Drugs.com = {{drugs.com|monograph|methscopolamine-bromide}}
	| CASNo_Ref = {{cascite|correct|CAS}}
			| MedlinePlus = a606008
⚫	| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
		⚫	| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫	| ChemSpiderID = 21106347
		⚫	| pregnancy_US = <!-- A / B / C / D / X -->
⚫	| ChEMBL_Ref = {{ebicite|changed|EBI}}
		⚫	| pregnancy_category =
⚫	| ChEMBL = 376897
			| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
	| UNII_Ref = {{fdacite|correct|FDA}}
			| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
	| UNII = RTN51LK7WL
			| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
⚫	| InChI = 1/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1
			| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
	| InChIKey = LZCOQTDXKCNBEE-IKIFYQGPBD
		⚫	| legal_status =
⚫	| smiles = OC(c1ccccc1)C(=O)O2C3(C)(C)(C2)4O34
		⚫	| routes_of_administration = <!--Pharmacokinetic data-->
⚫	| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
		⚫	| bioavailability =
	| StdInChI = 1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1
			| protein_bound =
⚫	| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
			| metabolism =
⚫	| StdInChIKey = LZCOQTDXKCNBEE-IKIFYQGPSA-N
		⚫	| elimination_half-life = 3–4 hrs
	| CAS_number = 155-41-9
	| ATC_prefix = none		| excretion = <!--Identifiers-->
	| ATC_suffix =		| CAS_number = 155-41-9
	| PubChem = 441342		| ATC_prefix = A03
	| DrugBank = APRD00314		| ATC_suffix = BB03
			| ATC_supplemental = {{ATC|S01|FA03}}
⚫	| C = 18 | H = 24 | N = 1 | O = 4
			| PubChem = 441342
⚫	| molecular_weight = 318.388 g/mol
			| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
⚫	| bioavailability =
	| protein_bound =		| DrugBank = DB00462
		⚫	| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫	| metabolism =
		⚫	| ChemSpiderID = 21106347
⚫	| elimination_half-life = 3 - 4hr
	| excretion =		| UNII_Ref = {{fdacite|correct|FDA}}
	| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->		| UNII = RTN51LK7WL
	| pregnancy_US = <!-- A / B / C / D / X -->		| KEGG = D00715
		⚫	| ChEMBL_Ref = {{ebicite|correct|EBI}}
⚫	| pregnancy_category=
			| PDB_ligand = 3C0
⚫	| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
		⚫	| ChEMBL = 376897
⚫	| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
	| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->		<!--Chemical data-->| C = 18
	| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->		| H = 24
	| legal_status =		| N = 1
		⚫	| O = 4
⚫	| routes_of_administration =
		⚫	| molecular_weight = 318.388 g/mol (398.297 g/mol with bromide)
		⚫	| smiles = OC(c1ccccc1)C(=O)O2C3(C)(C)(C2)4O34
		⚫	| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
		⚫	| StdInChI = 1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12-,13-,14-,15+,16-,17+/m1/s1
		⚫	| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
		⚫	| StdInChIKey = LZCOQTDXKCNBEE-IKIFYQGPSA-N
	}}		}}
	'''Methscopolamine''', usually provided as a bromide salt (Pamine), is an oral ] used along with other medications to treat ]s by reducing ] ] secretion. With the advent of proton pump inhibitors and antihistamine medications it is rarely used for this anymore. It can also be used for stomach or intestinal spasms, to reduce ], and to treat ]. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold,irritable bowel syndrome and allergy medications (Extendryl, AlleRx, Rescon).		'''Methylscopolamine''' or '''methscopolamine''', usually provided as the ] or ] salt, is an oral ] used along with other medications to treat ]s by reducing ] ] secretion.<ref>Drugs.com: </ref> Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce ], and to treat ]. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications<ref>{{cite book | vauthors = Gennaro AR | publisher = Remington | title = The Science and Practice of Pharmacy | pages = 402–403, 1025 | isbn = 0912734043 }}</ref>
	Methscopolamine, a ]ated derivative of ], is a ] structurally similar to the neurotransmitter ]. Its ] involves blocking the ]s.		Methscopolamine, a ]ated derivative of ], is a ] structurally similar to the neurotransmitter ]. Its ] involves blocking the ]s.
			<!-- Society and culture -->
			It was patented in 1902 and approved for medical use in 1947.<ref>{{cite book | vauthors = Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=446 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA446 |language=en}}</ref> Methscopolamine is an FDA-approved analog to ].
			==Brand names==
			Brand names include Extendryl, AlleRx, Rescon, Pamine.
			==References==
			{{reflist}}
			{{Drugs for functional gastrointestinal disorders}}
			{{Muscarinic acetylcholine receptor modulators}}
⚫	]
	]		]
			]
			]
			]
			]
			]
		⚫	]
	]		]
	]		]
	]
	{{Pharma-stub}}		{{gastrointestinal-drug-stub}}