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{{short description|Chemical compound}} |
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{{drugbox |
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{{Drugbox |
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| verifiedrevid = 293561583 |
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| Verifiedfields = changed |
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| IUPAC_name = pyridin-3-ylmethanol |
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| Watchedfields = changed |
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| image = Nicotinyl alcohol.png |
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| verifiedrevid = 387076743 |
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| width = 120px |
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| IUPAC_name = (Pyridin-3-yl)methanol |
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| CASNo_Ref = {{cascite}} |
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| image = Nicotinyl alcohol.png |
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| CAS_number = 100-55-0 |
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| width = 120px |
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| ATC_prefix = C10 |
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<!--Clinical data--> |
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| ATC_suffix = AD05 |
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| tradename = |
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| ATC_supplemental = {{ATC|C04|AC02}} |
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| Drugs.com = {{drugs.com|monograph|nitroglycerin}} |
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| PubChem = 7510 |
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| DrugBank = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 100-55-0 |
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| UNII_Ref = {{fdacite|changed|FDA}} |
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| UNII = 9TF312056Y |
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| ATC_prefix = C10 |
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| ATC_suffix = AD05 |
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| ATC_supplemental = {{ATC|C04|AC02}} |
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| ChEBI = 45213 |
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| PubChem = 7510 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChemSpiderID = 7229 |
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| synonyms = Roniacol; Roniacol tartrate; Nicotinyl tartrate;<ref>{{cite journal | pmid=14066712 | journal = ] | date = 1963 | volume = 186 | pages = 1013 | author = Norwood WF | title = Vasodilator Effects of Nicotinyl Tartrate (Roniacol Tartrate) | doi = 10.1001/jama.1963.03710110065012 }}</ref> Nicotinyl alcohol tartrate; Nicotinic alcohol; Pyridylcarbinol |
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<!--Chemical data--> |
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| C=6 | H=7 | N=1 | O=1 |
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| smiles = OCc1cccnc1 |
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| smiles = OCc1cccnc1 |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| C=6|H=7|N=1|O=1 |
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| StdInChI = 1S/C6H7NO/c8-5-6-2-1-3-7-4-6/h1-4,8H,5H2 |
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| molecular_weight = 109.126 g/mol |
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| bioavailability = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
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| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --> |
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| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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}} |
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}} |
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'''Nicotinyl alcohol''' ('''pyridylcarbinol''') is a ] derivative used as a ] and as a ]. |
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'''Nicotinyl alcohol''' ('''pyridylcarbinol''') is a ] derivative used as a ] and as a ]. It causes flushing and may decrease blood pressure.<ref>{{cite web|url=http://www.online-medical-dictionary.org/Ronicol+Retard.asp?q=Ronicol+Retard|work=Medical Dictionary Online|title=Ronicol Retard|date=2012|access-date=July 27, 2012|url-status=dead|archive-url=https://web.archive.org/web/20110614234933/http://www.online-medical-dictionary.org/Ronicol+Retard.asp?q=Ronicol+Retard|archive-date=June 14, 2011}}</ref> |
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It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 °C.{{citation needed|date=June 2016}} |
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] is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like ],<ref>{{cite journal |vauthors=Richter IH, Fogel M, Fabricant H |title=An evaluation of roniacol tartrate in arteriosclerosis obliterans |journal=New York State Journal of Medicine |volume=51 |issue=10 |pages=1303–4 |year=1951 |pmid=14843421 }}</ref> ],<ref>{{Cite web|url=https://www.theodora.com/medical_dictionary/nicotine_nitrocellulose.html|title=Medical Dictionary, Dictionary of medicine and human biology, medical, biological and chemical terminology|website=www.theodora.com}}</ref> thromboangiitis obliterans (]),<ref>{{Cite web|url=https://es.slideshare.net/ravinarwal/buergers-disease-by-dr-ravinder-narwal|title=Buergers disease by dr .ravinder narwal|date=July 7, 2011|at=page 18}}</ref> arterial embolism, ] or migraine associated with vascular spasm. |
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Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to ],<ref>{{cite journal |vauthors=Gillhespy, RO |title=Nicotinyl Alcohol Tartrate in Intermittent Claudication |journal=British Medical Journal |volume=18 |issue=2 |pages=207–208 |year=1957 |doi=10.1136/bmj.1.5012.207|pmid=13383231 |pmc=1974214 }}</ref> ulcer healing and others.<ref>{{cite journal |vauthors=Fisher MM, Tebrock HW |title=Nicotinic alcohol (roniacol) in peripheral vascular diseases and allied conditions: its use and limitations |journal=New York State Journal of Medicine |volume=53 |issue=1 |pages=65–8 |year=1953 |pmid=13025721 }}</ref> |
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== Derivatives == |
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At least a couple of uses for this agent were discovered over the years: |
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#] (Topanicate, MG 28362) |
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==References== |
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{{Reflist}} |
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{{Lipid modifying agents}} |
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{{Lipid modifying agents}} |
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{{Peripheral vasodilators}} |
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{{Peripheral vasodilators}} |
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{{cardiovascular-drug-stub}} |
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