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Octatropine methylbromide: Difference between revisions

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Revision as of 16:17, 29 July 2010 editPotatoBot (talk | contribs)Bots51,239 editsm Stub sorting and placement of stub template(s)← Previous edit Latest revision as of 18:40, 6 December 2023 edit undoBoghog (talk | contribs)Autopatrolled, Extended confirmed users, IP block exemptions, New page reviewers, Pending changes reviewers, Rollbackers, Template editors137,965 edits added missing chapters to book cites 
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{{Short description|Pharmaceutical drug}}
⚫ {{drugbox | verifiedrevid = 305248577
{{drugbox
|
| Verifiedfields = changed
| Watchedfields = changed
| UNII_Ref = {{fdacite|changed|FDA}}
⚫ | UNII = 62M960DHIL| verifiedrevid = 376110842
| IUPAC_name = (''endo'')-8,8-dimethyl-8-azoniabicyclooctan-3-yl] 2-propylpentanoate bromide | IUPAC_name = (''endo'')-8,8-dimethyl-8-azoniabicyclooctan-3-yl] 2-propylpentanoate bromide
| image = Octatropine methylbromide.svg | image = Octatropine methylbromide.svg
| CASNo_Ref = {{cascite}} | CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 80-50-2 | CAS_number = 80-50-2
| ATC_prefix = none | ATC_prefix = none
| ATC_suffix = | ATC_suffix =
| PubChem = 6647 | PubChem = 6647
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00517 | DrugBank = DB00517
| KEGG_Ref = {{keggcite|correct|kegg}}
| chemical_formula = C<sub>17</sub>H<sub>32</sub>NO<sub>2</sub><sup>+</sup>{{·}} Br<sup>−</sup>
| KEGG = D00232
| molecular_weight = 362.345 g/mol
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1186610
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 10482228
| smiles = CCCC(CCC)C(=O)O1C2CC(C1)2(C)C.
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C17H32NO2.BrH/c1-5-7-13(8-6-2)17(19)20-16-11-14-9-10-15(12-16)18(14,3)4;/h13-16H,5-12H2,1-4H3;1H/q+1;/p-1/t14-,15+,16+;
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = QSFKGMJOKUZAJM-CNKDKAJDSA-M
| C=17 | H=32 | N=1 | O=2 | Br=1
| synonyms = 8-Methyltropinium bromide 2- propylvalerate | synonyms = 8-Methyltropinium bromide 2- propylvalerate
| bioavailability = 10 to 25% (oral) | bioavailability = 10 to 25% (oral)
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| routes_of_administration = Oral | routes_of_administration = Oral
}} }}
'''Octatropine methylbromide''' (]) or '''anisotropine methylbromide''' (]), trade names '''Valpin''', '''Endovalpin''', '''Lytispasm''' and others,<ref name=DPA>{{cite book |author=David J. Triggle |coauthors=C. R. Ganellin, F. MacDonald |title=Dictionary of Pharmacological Agents |publisher=Chapman & Hall/CRC |location=Boca Raton |year=1997 |volume=2 |pages=p. 1467 |isbn=0-412-46630-9 |url=http://books.google.com/?id=A0THacd46ZsC}} Retrieved on August 31, 2008 through ].</ref> is a ] and ]. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of ],<ref>{{cite journal |author=Batterman RC, Mouratoff GJ, Kaufman JE |title=Anisotropine methylbromide: a new antispasmodic for gastrointestinal disorders |journal=Curr Ther Res Clin Exp |volume=5 |issue= |pages=213–8 |year=1963 |month=May |pmid=13966843 |doi= |url=}}</ref> and promoted as being more specific to the ] than other anticholinergics, although its selectivity was questioned in later studies.<ref>{{cite book |author=Gyermek, Laszlo |title=Pharmacology of antimuscarinic agents |publisher=CRC Press |location=Boca Raton |year=1998 |pages=p. 183 |isbn=0-8493-8559-8 |oclc= |url=http://books.google.com/?id=_VyDxfdunv4C&pg=PA183&dq=anisotropine}} Retrieved on August 31, 2008 through Google Book Search.</ref><ref>{{cite journal |author=Bachrach WH |title=Clinical evaluation of anisotropine methyl bromide (valpin), an anticholinergic drug |journal=Am J Dig Dis |volume=17 |issue=6 |pages=505–12 |year=1972 |month=June |pmid=4555460 |doi=10.1007/BF02231205}}</ref> '''Octatropine methylbromide''' (]) or '''anisotropine methylbromide''' (]), trade names '''Valpin''', '''Endovalpin''', '''Lytispasm''' and others,<ref name=DPA>{{cite book | vauthors = Triggle DJ, Ganellin CR, MacDonald F |title=Dictionary of Pharmacological Agents |publisher=Chapman & Hall/CRC |location=Boca Raton |year=1997 |volume=2 |pages=1467 |isbn=0-412-46630-9 |url=https://books.google.com/books?id=A0THacd46ZsC}} Retrieved on August 31, 2008 through ].</ref> is a ] and ]. It was introduced to the U.S. market in 1963 as an adjunct in the treatment of ],<ref>{{cite journal | vauthors = Batterman RC, Mouratoff GJ, Kaufman JE | title = Anisotropine methylbromide: a new antispasmodic for gastrointestinal disorders | journal = Current Therapeutic Research, Clinical and Experimental | volume = 5 | pages = 213–218 | date = May 1963 | pmid = 13966843 }}</ref> and promoted as being more specific to the ] than other anticholinergics, although its selectivity was questioned in later studies.<ref>{{cite book | vauthors = Gyermek L | chapter = Semisynthetic Derivatives of Tropane Alkaloids and o Other Atropine Esters |title=Pharmacology of antimuscarinic agents |publisher=CRC Press |location=Boca Raton |year=1998 |pages=183 |isbn=0-8493-8559-8 | chapter-url=https://books.google.com/books?id=_VyDxfdunv4C&q=anisotropine&pg=PA183}} Retrieved on August 31, 2008 through Google Book Search.</ref><ref>{{cite journal | vauthors = Bachrach WH | title = Clinical evaluation of anisotropine methyl bromide (valpin), an anticholinergic drug | journal = The American Journal of Digestive Diseases | volume = 17 | issue = 6 | pages = 505–512 | date = June 1972 | pmid = 4555460 | doi = 10.1007/BF02231205 | s2cid = 7836183 }}</ref>


Octatropine has been superseded by more effective agents in the treatment of peptic ulcer disease, and is no longer used. It is still sold in some countries in combination with other drugs, such as ] and ]. Octatropine has been superseded by more effective agents in the treatment of peptic ulcer disease, and is no longer used. It is still sold in some countries in combination with other drugs, such as ] and ].


==References== == References ==
{{Reflist}} {{Reflist}}


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{{Anticholinergics}}
{{Drugs for functional gastrointestinal disorders}} {{Drugs for functional gastrointestinal disorders}}
{{Muscarinic acetylcholine receptor modulators}}


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{{gastrointestinal-drug-stub}} {{gastrointestinal-drug-stub}}
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