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{{Short description|Oral fixed dose combination prescription medication}} |
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{{Redirect-acronym|Paramax|the audio brand used for ]}} |
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{{Redirect|Paramax}} |
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{{Drugbox |
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{{Drugbox |
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| verifiedrevid = 394193879 |
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| type = combo |
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| component1 = Paracetamol |
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<!--Combo data--> |
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| class1 = ] |
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| type = combo |
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| component2 = Metoclopramide |
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| component1 = Paracetamol |
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| class2 = ] |
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| class1 = ] |
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| CAS_number = |
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| component2 = Metoclopramide |
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| class2 = ] |
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<!--Clinical data--> |
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| DrugBank = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_category= |
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| pregnancy_category = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_AU = S3 |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = POM |
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| legal_UK = POM |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = ] <small>(])</small> |
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| legal_status = ] <small>(])</small> |
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| routes_of_administration = Oral |
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| routes_of_administration = Oral |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 73802-00-3 |
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| ATC_prefix = |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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<!--Chemical data--> |
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'''Paracetamol/metoclopramide hydrochloride''' is an oral ] prescription medication containing the ] ] (500 mg) and the ] ] (5 mg). Formulated as a ] and as ]s of a water-soluble ], it is sold under the trade name '''Paramax''' by ],<ref name=emc> (accessed 22 April 2008)</ref> and in Switzerland as Migraeflux MCP, in Australia it is sold as Meteclomax and Anagraine. |
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'''Paracetamol/metoclopramide hydrochloride''' is an oral ] prescription medication containing the ] ] (500 mg) and the ] ] (5 mg). Formulated as a ] and as ]s of a water-soluble ], it is sold under the trade name '''Paramax''' by ],<ref name=emc>{{Dead link|date=January 2025 |bot=InternetArchiveBot |fix-attempted=yes }} (accessed 22 April 2008)</ref> and in Switzerland as Migraeflux MCP,<ref></ref> in Australia it is sold as Meteclomax and Anagraine. |
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The combination is used to treat the symptoms of ], both to relieve ] (the analgesic) and to treat associated ] and ] (the antiemetic). In addition to its direct anti-emetic effect metoclopramide also stimulates gastric emptying (]), which is often delayed during migraine attacks, and accelerates the ] of paracetamol.<ref name=emc /> However the improvement in paracetamol absorption has been questioned.<ref name="pmid6849786">{{cite journal |author=Dougall JR, Cunningham B, Nimmo WS |title=Paracetamol absorption from Paramax, Panadol and Solpadeine |journal=Br J Clin Pharmacol |volume=15 |issue=4 |pages=487–9 |year=1983 |month=April |pmid=6849786 |doi= |url= |pmc=1427806}} - {{PMC|6849786}}<br />'''Subsequent response from Beecham Research Laboratories:'''<br/>*{{cite journal |author=Boston PF |title=Paracetamol absorption from Paramax, Panadol and Solpadeine |journal=Br J Clin Pharmacol |volume=16 |issue=5 |pages=578 |year=1983 |month=November |pmid=6639847 |doi= |url= |pmc=1428077}} - {{PMC|6639847}}</ref> |
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The combination is used to treat the symptoms of ], both to relieve ] (the analgesic) and to treat associated ] and ] (the antiemetic). In addition to its direct anti-emetic effect metoclopramide also stimulates gastric emptying (]), which is often delayed during migraine attacks, and accelerates the ] of paracetamol.<ref name=emc /> However the improvement in paracetamol absorption has been questioned.<ref name="pmid6849786">{{cite journal |vauthors=Dougall JR, Cunningham B, Nimmo WS |title=Paracetamol absorption from Paramax, Panadol and Solpadeine |journal=Br J Clin Pharmacol |volume=15 |issue=4 |pages=487–9 |date=April 1983 |pmid=6849786 |doi= 10.1111/j.1365-2125.1983.tb01534.x|pmc=1427806}}<br />'''Subsequent response from Beecham Research Laboratories:'''<br/>*{{cite journal |author=Boston PF |title=Paracetamol absorption from Paramax, Panadol and Solpadeine |journal=Br J Clin Pharmacol |volume=16 |issue=5 |pages=578 |date=November 1983 |pmid=6639847 |doi= 10.1111/j.1365-2125.1983.tb02223.x|pmc=1428077}}</ref> |
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The combination of metoclopramide to the paracetamol has been shown to enhance the analgesia relief when used to treat the pain of ].<ref name="pmid6653133">{{cite journal |author=Matts SG, Boston PF |title=Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis |journal=Curr Med Res Opin |volume=8 |issue=8 |pages=547–52 |year=1983 |pmid=6653133 |doi= 10.1185/03007998309109796|url=}}</ref> |
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The combination of metoclopramide to the paracetamol has been shown to enhance the analgesia relief when used to treat the pain of ].<ref name="pmid6653133">{{cite journal |vauthors=Matts SG, Boston PF |title=Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis |journal=Curr Med Res Opin |volume=8 |issue=8 |pages=547–52 |year=1983 |pmid=6653133 |doi= 10.1185/03007998309109796}}</ref> |
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Whilst the individual component drugs may be prescribed individually, as a combination, it is only available as the branded Paramax preparation in the UK.<ref>{{cite web |title=Paramax (paracetamol, metoclopramide) |url=http://www.netdoctor.co.uk/medicines/100002012.html |date=05.03.2008 |publisher=NetDoctor.co.uk |accessdate=2008-04-22}}</ref>. In the UK there are only two other combination analgesics with antiemetics (i.e., anti-nausea) products available: MigraMax (] with metoclopramide) and the ] ] (paracetamol and codeine for analgesia, with ] as the antiemetic).<ref>{{cite book |title=] |edition=55 |date=March 2008 |chapter=4.7.4.1 Treatment of acute migraine |pages=p.239}}</ref> The role for these products is between just the use of simple analgesics (paracetamol or ibuprofen) and the ] class of drugs; although the latter are not options during pregnancy.<ref name="pmid9825951">{{cite journal |author=Pfaffenrath V, Rehm M |title=Migraine in pregnancy: what are the safest treatment options? |journal=Drug Saf |volume=19 |issue=5 |pages=383–8 |year=1998 |month=November |pmid=9825951 |doi= |url=}}</ref> In the elderly although triptans are generally avoided, so too are antiemetics such as metoclopramide due to higher risks of side effects. In Australia and New Zealand, the combination is available without prescription from pharmacies. <ref name="pmid16872231">{{cite journal |author=Sarchielli P, Mancini ML, Calabresi P |title=Practical considerations for the treatment of elderly patients with migraine |journal=Drugs Aging |volume=23 |issue=6 |pages=461–89 |year=2006 |pmid=16872231 |doi= 10.2165/00002512-200623060-00003|url=}}</ref> |
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Whilst the individual component drugs may be prescribed individually, as a combination, it is only available as the branded Paramax preparation in the UK.<ref>{{cite web |title=Paramax (paracetamol, metoclopramide) |url=http://www.netdoctor.co.uk/medicines/100002012.html |orig-year=2008 |date=June 2, 2017 |publisher=NetDoctor.co.uk |access-date=2008-04-22}}</ref> In the UK there are only two other combination analgesics with antiemetics (i.e., anti-nausea) products available: MigraMax (] with metoclopramide) and the ] ] (paracetamol and codeine for analgesia, with ] as the antiemetic).<ref>{{cite book |title=] |edition=55th |date=March 2008 |chapter=4.7.4.1 Treatment of acute migraine |pages=239}}</ref> The role for these products is between just the use of simple analgesics (paracetamol or ibuprofen) and the ] class of drugs; although the latter are not options during pregnancy.<ref name="pmid9825951">{{cite journal |vauthors=Pfaffenrath V, Rehm M |title=Migraine in pregnancy: what are the safest treatment options? |journal=Drug Saf |volume=19 |issue=5 |pages=383–8 |date=November 1998 |pmid=9825951 |doi= 10.2165/00002018-199819050-00005|s2cid=21807755 }}</ref> In the elderly although triptans are generally avoided, so too are antiemetics such as metoclopramide due to higher risks of side effects. In Australia and New Zealand, the combination is available without prescription from pharmacies.<ref name="pmid16872231">{{cite journal |vauthors=Sarchielli P, Mancini ML, Calabresi P |title=Practical considerations for the treatment of elderly patients with migraine |journal=Drugs Aging |volume=23 |issue=6 |pages=461–89 |year=2006 |pmid=16872231 |doi= 10.2165/00002512-200623060-00003|s2cid=8746056 }}</ref> |
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==References== |
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==References== |
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{{analgesic-stub}} |
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{{Analgesics}} |
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{{Anti-inflammatory products}} |
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{{DEFAULTSORT:Paracetamol Metoclopramide}} |
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