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Revision as of 14:28, 6 December 2010 editBeetstra (talk | contribs)Edit filter managers, Administrators172,079 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: InChI1->InChI StdInChI StdInChIKey.← Previous edit Latest revision as of 00:46, 23 January 2023 edit undoEntranced98 (talk | contribs)Extended confirmed users, Pending changes reviewers, Rollbackers174,326 edits Importing Wikidata short description: "Chemical compound"Tag: Shortdesc helper 
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{{Short description|Chemical compound}}
{{Drugbox {{Drugbox
| Verifiedfields = changed
⚫ | IUPAC_name =
| Watchedfields = changed
⚫ | image = Policresulen.png
| verifiedrevid = 464209044
⚫ | ChemSpiderID = 2312470
⚫ | IUPAC_name =
| InChI = 1/C23H24O12S3/c1-11-4-18(24)20(36(27,28)29)8-14(11)6-16-10-22(38(33,34)35)23(26)17(13(16)3)7-15-9-21(37(30,31)32)19(25)5-12(15)2/h4-5,8-10,24-26H,6-7H2,1-3H3,(H,27,28,29)(H,30,31,32)(H,33,34,35)
⚫ | image = Policresulen.png
| InChIKey = ACZKMKGNTMOPBD-UHFFFAOYAL
<!-- Clinical data -->
| StdInChI = 1S/C23H24O12S3/c1-11-4-18(24)20(36(27,28)29)8-14(11)6-16-10-22(38(33,34)35)23(26)17(13(16)3)7-15-9-21(37(30,31)32)19(25)5-12(15)2/h4-5,8-10,24-26H,6-7H2,1-3H3,(H,27,28,29)(H,30,31,32)(H,33,34,35)
| tradename =
| StdInChIKey = ACZKMKGNTMOPBD-UHFFFAOYSA-N
| Drugs.com = {{drugs.com|international|policresulen}}
⚫ | CAS_number = 101418-00-2
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | CAS_supplemental =
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | ATC_prefix = D08
⚫ | pregnancy_category =
⚫ | ATC_suffix = AE02
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
⚫ | ATC_supplemental = {{ATC|G01|AX03}} {{ATCvet|G51|AD02}}
| PubChem = 3050404 | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| DrugBank = | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
⚫ | chemical_formula = (C<sub>9</sub>H<sub>8</sub>O<sub>4</sub>S)<sub>n</sub>
| C= | H= | N= | O= | legal_status =
⚫ | molecular_weight = variable
| smiles = O=S(=O)(O)c1cc(c(cc1O)C)Cc2cc(c(O)c(c2C)Cc3cc(c(O)cc3C)S(=O)(=O)O)S(=O)(=O)O
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =
⚫ | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫ | pregnancy_US = <!-- A / B / C / D / X -->
⚫ | pregnancy_category=
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
⚫ | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =
| routes_of_administration = topical | routes_of_administration = topical
<!-- Pharmacokinetic data -->
⚫ | bioavailability =
⚫ | protein_bound =
⚫ | metabolism =
⚫ | elimination_half-life =
⚫ | excretion =
<!-- Identifiers -->
| CAS_number_Ref = {{cascite|changed|??}}
⚫ | CAS_number = 101418-00-2
⚫ | CAS_supplemental =
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = 6I19M5GB0G
⚫ | ATC_prefix = D08
⚫ | ATC_suffix = AE02
⚫ | ATC_supplemental = {{ATC|G01|AX03}} {{ATCvet|G51|AD02}}
| PubChem = 3050404
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
⚫ | ChemSpiderID = none
<!-- Chemical data -->
⚫ | chemical_formula = (C<sub>9</sub>H<sub>8</sub>O<sub>4</sub>S)<sub>n</sub>
⚫ | molecular_weight = variable
}} }}


'''Policresulen''' is the polycondensation product of ] and ].<ref name=Kim2015>{{cite journal | vauthors = Kim EC, Park JB, Hong JY, Kang KL | title = Extensive gingival necrosis and sequestration of the alveolar bone caused by methimazole-induced neutropenia and three-year follow-up | journal = Journal of Periodontal & Implant Science | volume = 45 | issue = 2 | pages = 76–80 | date = April 2015 | doi = 10.5051/jpis.2015.45.2.76 | pmid = 25932342 | pmc = 4415005 | doi-access = free }}</ref> It is used as a topical ] and ]<ref>{{cite web | url = https://www.drugs.com/international/policresulen.html | title = Policresulen | publisher = ]}}</ref> in infectious and other lesions of the ], like gynecological infections, anal hemorrhoids as well as ulcers of the oral cavity including ]. In some countries it is marketed under the trade name '''Albothyl''' or '''Polilen''' (Taiwan) or Faktu (combination with ]).
'''Policresulen''' is a topical haemostatic and ]. It is indicated for common anal disorders, such as hemorrhoids, and for gynecological infections. In some countries it is marketed under the trade name '''Albothyl''' or '''Polilen''' (Taiwan) .


==Medical uses==
<references/>
Policresulen is used in the treatment of gynecological infections since the 1950s.<ref name=Renner1954>{{cite journal | last = Renner | first = Alfred | title = Albothyl, a substance with a new mechanism of action in the treatment of gynecological diseases | journal = Medizinische Klinik | volume = 49 | issue = 50 | pages = 1998–1999 | date = December 1954 | pmid = 13235222 }}</ref> The range of applications soon widened to include the therapy of other mucous membrane and skin lesions. The mechanism of action is twofold: next to its antiseptic effect, policresulen promotes the selective coagulation of necrotic and pathologically altered tissues while leaving healthy tissues intact.<ref name=Kim2015/> The shedding of necrotic tissues is accompanied by the reepithelialization of the mucosal (or dermal) wound tissues.<ref name=Kim2015/>

==References==
{{reflist}}


{{Antiseptics and disinfectants}} {{Antiseptics and disinfectants}}
{{Gynecological anti-infectives and antiseptics}} {{Gynecological anti-infectives and antiseptics}}

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{{dermatologic-drug-stub}} {{dermatologic-drug-stub}}
{{genito-urinary-drug-stub}} {{genito-urinary-drug-stub}}

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