4-Hydroxybenzoate geranyltransferase

4-hydroxybenzoate geranyltransferase (EC 2.5.1.93, PGT1, PGT2, 4HB geranyltransferase, 4HB:geranyltransferase, p-hydroxybenzoate geranyltransferase, PHB geranyltransferase, geranyl diphosphate:4-hydroxybenzoate geranyltransferase) is an enzyme with systematic name geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase. This enzyme catalyses the following chemical reaction

geranyl diphosphate + 4-hydroxybenzoate

\rightleftharpoons

3-geranyl-4-hydroxybenzoate + diphosphate

The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg.

References

Ohara K, Muroya A, Fukushima N, Yazaki K (June 2009). "Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid". The Biochemical Journal. 421 (2): 231–41. doi:10.1042/bj20081968. PMID 19392660.
Mühlenweg A, Melzer M, Li SM, Heide L (July 1998). "4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase". Planta. 205 (3): 407–13. doi:10.1007/s004250050337. PMID 9640665.
Yazaki K, Kunihisa M, Fujisaki T, Sato F (February 2002). "Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis". The Journal of Biological Chemistry. 277 (8): 6240–6. doi:10.1074/jbc.m106387200. PMID 11744717.

External links

4-hydroxybenzoate+geranyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Transferases: alkyl and aryl (EC 2.5)
2.5.1	Dimethylallyltranstransferase Thiaminase I Methionine adenosyltransferase Riboflavin synthase Dihydropteroate synthase Spermidine synthase Glutathione S-transferase Farnesyl-diphosphate farnesyltransferase Spermine synthase Alkylglycerone phosphate synthase Farnesyltransferase Geranylgeranyltransferase type 1 Porphobilinogen deaminase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 2.5.1