5-Histidylcysteine sulfoxide synthase is the initial enzyme in the ovothiol biosynthetic pathway. It facilitates the oxidative addition of cysteine to histidine, resulting in the formation of 5-histidylcysteine sulfoxide. This enzyme is present in trypanosomes, where it also exhibits S-Adenosyl methionine (SAM)-dependent methyltransferase activity, catalyzing the methylation of the N1 position.
References
- Braunshausen, A. & Seebeck, F. P. Identification and characterization of the first ovothiol biosynthetic enzyme. J. Am. Chem. Soc. 133, 1757-1759 (2011).
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