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FABP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NNT, 1TOU, 1TOW, 2HNX, 2NNQ, 3FR2, 3FR4, 3FR5, 3P6C, 3P6D, 3P6E, 3P6F, 3P6G, 3P6H, 3Q6L, 3RZY, 4NNS, 5EDB, 5EDC, 5D48, 5D4A, 5D45, 5D47
Identifiers
Aliases	FABP4, A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4
External IDs	OMIM: 600434; MGI: 88038; HomoloGene: 36067; GeneCards: FABP4; OMA:FABP4 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.13 Start 81,478,419 bp End 81,483,236 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 A1|3 2.56 cM Start 10,269,148 bp End 10,273,636 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in abdominal fat pericardium skin of hip subcutaneous adipose tissue vena cava lactiferous duct synovial joint trabecular bone gastric mucosa thoracic diaphragm Top expressed in intercostal muscle tunica adventitia of aorta transitional epithelium of urinary bladder brown adipose tissue tunica media of zone of aorta parotid gland decidua gastrula aortic valve ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity fatty acid binding lipid binding long-chain fatty acid transporter activity long-chain fatty acid binding hormone receptor binding Cellular component cytosol lipid droplet extracellular exosome nucleus cytoplasm Biological process white fat cell differentiation regulation of inflammatory response cytokine production cholesterol homeostasis positive regulation of inflammatory response negative regulation of transcription, DNA-templated cellular response to lithium ion negative regulation of protein kinase activity brown fat cell differentiation triglyceride catabolic process cellular response to tumor necrosis factor transport response to bacterium long-chain fatty acid transport positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2167 11770 Ensembl ENSG00000170323 ENSMUSG00000062515 UniProt P15090 P04117 RefSeq (mRNA) NM_001442 NM_024406 RefSeq (protein) NP_001433 NP_077717 Location (UCSC) Chr 8: 81.48 – 81.48 Mb Chr 3: 10.27 – 10.27 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

aP2 (adipocyte Protein 2) is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs has the possibility of treating heart disease and the metabolic syndrome.

See also

• Fatty acid-binding protein

References

1. ^ GRCh38: Ensembl release 89: ENSG00000170323 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062515 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID 2481498.
6. Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi:10.1016/j.ejmech.2017.07.022. PMID 28738306.
7. Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. Journal of Atherosclerosis and Thrombosis. 26 (3): 216–232. doi:10.5551/jat.48710. PMC 6402888. PMID 30726793.

External links

• FABP4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human FABP4 genome location and FABP4 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Fatty acid-binding protein, adipocyte
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Fatty acid-binding protein, adipocyte

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