After You've Gone may refer to:
Music
- "After You've Gone" (song), a 1918 song written by Turner Layton and Henry Creamer
- After You've Gone, an album by Lenny Solomon
- After You've Gone, a 2004 album by Barre Phillips, Tetsu Saitoh, William Parker, and Joëlle Léandre
Television and film
- After You've Gone (TV series), a 2007–2008 British sitcom
- After You've Gone, 1984 UK film starring Adrian Dunbar
- "After You've Gone", an episode of Jake and the Fatman
- "After You've Gone", an episode of True Detective
Literature
- After You've Gone, a 1989 short-story collection by Alice Adams
- After You've Gone, a 2007 novel by Joan Lingard
- After You've Gone: My Life After Maurie Fields, a 1998 book by Val Jellay
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