Altamaha may refer to:
- Altamaha chiefdom, a Native American chiefdom, part of the paramount chiefdom known as Ocute and later La Tama
- Altamaha, Georgia, an unincorporated community
- Altamaha River, in the U.S. state of Georgia
- Altamaha Technical College, a technical college in Jessup, Georgia
- Lake Altamaha, in Florida
- USS Altamaha, any of several US Navy ships
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