| biotin- ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.4.11 | ||||||||
| CAS no. | 37318-68-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a biotin- ligase (EC 6.3.4.11) is an enzyme that catalyzes the chemical reaction
- ATP + biotin + apo- AMP + diphosphate +
AMP + diphosphate + The 3 substrates of this enzyme are ATP, biotin, and ]], whereas its 3 products are AMP, diphosphate, and 3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo- ligase (AMP-forming). Other names in common use include biotin- synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, beta-methylcrotonyl coenzyme A holocarboxylase synthetase, and holocarboxylase-synthetase. This enzyme participates in biotin metabolism.
References
| Enzymes: CO CS and CN ligases (EC 6.1-6.3) | |
|---|---|
| 6.1: Carbon-Oxygen | |
| 6.2: Carbon-Sulfur | |
| 6.3: Carbon-Nitrogen | |
| Enzymes | |
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| Activity | |
| Regulation | |
| Classification | |
| Kinetics | |
| Types |
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