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CHMP4C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3C3R
Identifiers
Aliases	CHMP4C, SNF7-3, Shax3, VPS32C, charged multivesicular body protein 4C
External IDs	OMIM: 610899; MGI: 1913621; HomoloGene: 23544; GeneCards: CHMP4C; OMA:CHMP4C - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.13 Start 81,732,448 bp End 81,759,515 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 A1 Start 10,431,967 bp End 10,493,916 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid jejunal mucosa mucosa of ileum skin of arm palpebral conjunctiva parotid gland duodenum pancreatic epithelial cell gingival epithelium mucosa of colon Top expressed in interventricular septum ileum duodenum jejunum epithelium of stomach Paneth cell left colon ascending aorta parotid gland epithelium of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding Cellular component cytoplasm ESCRT III complex cytosol endosome membrane late endosome membrane midbody Flemming body Biological process regulation of centrosome duplication abscission viral budding via host ESCRT complex viral life cycle nucleus organization multivesicular body assembly regulation of mitotic spindle assembly endosomal transport ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway protein transport negative regulation of cytokinesis septum digestion after cytokinesis mitotic metaphase plate congression vacuolar transport macroautophagy mitotic cytokinesis checkpoint signaling midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92421 66371 Ensembl ENSG00000164695 ENSMUSG00000027536 UniProt Q96CF2 Q9D7F7 RefSeq (mRNA) NM_152284 NM_025519 RefSeq (protein) NP_689497 NP_079795 Location (UCSC) Chr 8: 81.73 – 81.76 Mb Chr 3: 10.43 – 10.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Charged multivesicular body protein 4c is a protein that in humans is encoded by the CHMP4C gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000164695 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027536 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M (Sep 2003). "The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting". J Biol Chem. 278 (40): 39104–13. doi:10.1074/jbc.M301604200. PMID 12860994.
6. Katoh K, Shibata H, Hatta K, Maki M (Dec 2003). "CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms". Arch Biochem Biophys. 421 (1): 159–65. doi:10.1016/j.abb.2003.09.038. PMID 14678797.
7. "Entrez Gene: CHMP4C chromatin modifying protein 4C".

External links

• Human CHMP4C genome location and CHMP4C gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. Bibcode:2003PNAS..10012414M. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Peck JW, Bowden ET, Burbelo PD (2004). "Structure and function of human Vps20 and Snf7 proteins". Biochem. J. 377 (Pt 3): 693–700. doi:10.1042/BJ20031347. PMC 1223912. PMID 14583093.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

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