Main article: Canoeing at the 2010 South American Games
The Men's C-2 500m event at the 2010 South American Games was held over March 28 at 10:20.
Medalists
| Gold | Silver | Bronze |
| Ronilson de Oliveira Erlon Silva  Brazil
|
Eduyn Labarca Edward Luciano Paredes  Venezuela
|
Anderson Ospina Jesús Felipe Ospina  Colombia
|
Results
| Rank | Athlete | Time |
|---|---|---|
|
Brazil Ronilson de Oliveira Erlon Silva |
1:46.45 |
|
Venezuela Eduyn Labarca Edward Luciano Paredes |
1:47.67 |
|
Colombia Anderson Ospina Jesús Felipe Ospina |
1:48.40 |
| 4 |  ChileJohnnathan Francisco Quitral Alvaro Dario Raguileo |
1:53.82 |
| 5 |  ArgentinaLeonardo Niveiro Roberto Palacios |
1:58.21 |