| Chronic allograft nephropathy | |
|---|---|
| Other names | Sclerosing/chronic allograft nephropathy |
 | |
| Micrograph of chronic allograft nephropathy. PAS stain. | |
| Specialty | Urology |
Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure, occurring months to years after the transplant.
Symptoms and signs
CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.
Pathology
The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.
Diagnosis
CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.
References
- Paul, LC. (Sep 1999). "Chronic allograft nephropathy: An update". Kidney Int. 56 (3): 783–93. doi:10.1046/j.1523-1755.1999.00611.x. PMID 10469349.
- ^ Joosten, SA.; Sijpkens, YW.; van Kooten, C.; Paul, LC. (Jul 2005). "Chronic renal allograft rejection: pathophysiologic considerations". Kidney Int. 68 (1): 1–13. doi:10.1111/j.1523-1755.2005.00376.x. PMID 15954891.
- Nankivell, BJ.; Chapman, JR. (Mar 2006). "Chronic allograft nephropathy: current concepts and future directions". Transplantation. 81 (5): 643–54. doi:10.1097/01.tp.0000190423.82154.01. PMID 16534463. S2CID 30085431.
- Fletcher, Jeffery T.; Nankivell, Brian J.; Alexander, Stephen I. (2009). "Chronic allograft nephropathy". Pediatric Nephrology. 24 (8). Springer Science and Business Media LLC: 1465–1471. doi:10.1007/s00467-008-0869-z. ISSN 0931-041X. PMC 2697362.