Cross the Line may refer to:
- Cross the Line, a 2016 novel in the Alex Cross series by James Patterson
- Cross the Line (Spanish: No matarás), a 2020 Spanish thriller film directed by David Victori
- "Cross the Line", a 1986 song by Spandau Ballet from the album Through the Barricades
- "Cross the Line", a 2003 song by Kabir Suman from the album Reaching Out
- "Cross the Line", a 2019 song by James Morrison from the album You're Stronger Than You Know
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