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DKK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JTK
Identifiers
Aliases	DKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDs	OMIM: 605415; MGI: 1890663; HomoloGene: 8681; GeneCards: DKK2; OMA:DKK2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q25 Start 106,921,802 bp End 107,283,806 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 131,791,053 bp End 131,886,065 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of hip buccal mucosa cell Achilles tendon testicle Skeletal muscle tissue of rectus abdominis hair follicle thoracic diaphragm right lung muscle of thigh Top expressed in vestibular membrane of cochlear duct external carotid artery internal carotid artery iris glomerulus umbilical cord conjunctival fornix saccule gastrula glomerular mesangium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-receptor binding receptor antagonist activity Cellular component extracellular region extracellular space Biological process positive regulation of canonical Wnt signaling pathway multicellular organism development negative regulation of Wnt signaling pathway Wnt signaling pathway negative regulation of canonical Wnt signaling pathway extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27123 56811 Ensembl ENSG00000155011 ENSMUSG00000028031 UniProt Q9UBU2 Q9QYZ8 RefSeq (mRNA) NM_014421 NM_020265 RefSeq (protein) NP_055236 NP_064661 Location (UCSC) Chr 4: 106.92 – 107.28 Mb Chr 3: 131.79 – 131.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.

It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

See also

• Hairy palms and soles

References

1. ^ GRCh38: Ensembl release 89: ENSG00000155011 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028031 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
6. ^ "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".
7. Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, et al. (December 2018). "Regional Control of Hairless versus Hair-Bearing Skin by Dkk2". Cell Reports. 25 (11): 2981–2991.e3. doi:10.1016/j.celrep.2018.11.017. PMC 6345517. PMID 30509557.

Further reading

• Wu W, Glinka A, Delius H, Niehrs C (2001). "Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling". Current Biology. 10 (24): 1611–4. doi:10.1016/S0960-9822(00)00868-X. PMID 11137016. S2CID 6397269.
• Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C (May 2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136. S2CID 4323027.
• Li L, Mao J, Sun L, Liu W, Wu D (February 2002). "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled". The Journal of Biological Chemistry. 277 (8): 5977–81. doi:10.1074/jbc.M111131200. PMID 11742004.
• Brott BK, Sokol SY (September 2002). "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins". Molecular and Cellular Biology. 22 (17): 6100–10. doi:10.1128/MCB.22.17.6100-6110.2002. PMC 133995. PMID 12167704.
• Mao B, Niehrs C (January 2003). "Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling". Gene. 302 (1–2): 179–83. doi:10.1016/S0378-1119(02)01106-X. PMID 12527209.
• Kuphal S, Lodermeyer S, Bataille F, Schuierer M, Hoang BH, Bosserhoff AK (August 2006). "Expression of Dickkopf genes is strongly reduced in malignant melanoma". Oncogene. 25 (36): 5027–36. doi:10.1038/sj.onc.1209508. PMID 16568085. S2CID 12065588.

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