Fibrin monomers are monomers of fibrin which are formed by the cleavage of fibrinogen by thrombin. Levels of fibrin monomers can be measured using blood tests and can serve as a marker of in vivo fibrinogenesis and coagulation activation. They may be useful in the evaluation of hypercoagulability, as reflected in research studies done using fibrin monomers.
Levels of fibrin monomers may be increased with pregnancy and by estrogen-containing combined birth control pills.
Research
Significance in venous thromboembolism
Increased amount of soluble fibrin monomers in the blood along with serum D-dimers have been found to be indicators of venous thromboembolism (VTE). Detection of VTE in such a way have implications for treating VTE taking place during pregnancy and after hepatobiliary-pancreatic surgery.
References
- ^ Refaai MA, Riley P, Mardovina T, Bell PD (November 2018). "The Clinical Significance of Fibrin Monomers". Thromb Haemost. 118 (11): 1856–1866. doi:10.1055/s-0038-1673684. PMID 30312978.
- ^ Douxfils J, Morimont L, Bouvy C (November 2020). "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost. 46 (8): 872–886. doi:10.1055/s-0040-1714140. PMID 33080636. S2CID 224821517.
- Farris M, Bastianelli C, Rosato E, Brosens I, Benagiano G (October 2017). "Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. effects on hemostasis". Expert Rev Clin Pharmacol. 10 (10): 1129–1144. doi:10.1080/17512433.2017.1356718. PMID 28712325. S2CID 205931204.
- ^ Grossman, Karin B.; Arya, Roopen; Peixoto, Alberto B.; Akolekar, Ranjit; Staboulidou, Ismini; Nicolaides, Kypros H. (October 2016). "Maternal and pregnancy characteristics affect plasma fibrin monomer complexes and D-dimer reference ranges for venous thromboembolism in pregnancy". American Journal of Obstetrics and Gynecology. 215 (4): 466.e1–466.e8. doi:10.1016/j.ajog.2016.05.013. PMID 27179442.
- ^ Hayashi, Hikaru; Shimizu, Akira; Kubota, Koji; Notake, Tsuyoshi; Sugenoya, Shinsuke; Masuo, Hitoshi; Hosoda, Kiyotaka; Yasukawa, Koya; Kobayashi, Ryoichiro; Soejima, Yuji (January 2022). "Asymptomatic Venous Thromboembolism After Hepatobiliary–Pancreatic Surgery: Early Detection Using D-dimer and Soluble Fibrin Monomer Complex Levels". Annals of Gastroenterological Surgery. 6 (1): 109–118. doi:10.1002/ags3.12495. ISSN 2475-0328. PMC 8786684. PMID 35106421.
| Hematology blood tests | |
|---|---|
| Complete blood count | |
| Other tests of red blood cells | |
| Coagulation | |
| Other | |