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Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, chondroitin synthase, glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase. This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan ${\displaystyle \rightleftharpoons }$ UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan

This enzyme is involved in the biosynthesis of chondroitin sulfate.

References

1. Rohrmann K, Niemann R, Buddecke E (May 1985). "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of Biochemistry. 148 (3): 463–9. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
2. Kitagawa H, Uyama T, Sugahara K (October 2001). "Molecular cloning and expression of a human chondroitin synthase". The Journal of Biological Chemistry. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
3. DeAngelis PL, Padgett-McCue AJ (August 2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". The Journal of Biological Chemistry. 275 (31): 24124–9. doi:10.1074/jbc.M003385200. PMID 10818104.
4. Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K (June 2002). "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". The Journal of Biological Chemistry. 277 (24): 21567–75. doi:10.1074/jbc.M201719200. PMID 11943778.

External links

• Glucuronosyl-N-acetylgalactosaminyl-proteoglycan+4-beta-N-acetylgalactosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 2.4.1