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HIRIP3
Identifiers
Aliases	HIRIP3, HIRA interacting protein 3
External IDs	OMIM: 603365; MGI: 2142364; HomoloGene: 18218; GeneCards: HIRIP3; OMA:HIRIP3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p11.2 Start 29,992,330 bp End 29,996,074 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 126,461,144 bp End 126,464,549 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte left testis right testis ganglionic eminence ventricular zone apex of heart C1 segment secondary oocyte gastrocnemius muscle muscle of thigh Top expressed in zygote otic vesicle neural layer of retina secondary oocyte tail of embryo hand ventricular zone primary oocyte genital tubercle epiblast More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 8479 233876 Ensembl ENSG00000149929 ENSMUSG00000042606 UniProt Q9BW71 Q8BLH7 RefSeq (mRNA) NM_003609 NM_001197323 NM_172746 RefSeq (protein) NP_001184252 NP_003600 NP_766334 Location (UCSC) Chr 16: 29.99 – 30 Mb Chr 7: 126.46 – 126.46 Mb PubMed search
Wikidata
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HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene.

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a protein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000149929 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000042606 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC 109139. PMID 9710638.
6. ^ "Entrez Gene: HIRIP3 HIRA interacting protein 3".

Further reading

• Assrir N, Filhol O, Galisson F, Lipinski M (2007). "HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2". Biol. Chem. 388 (4): 391–8. doi:10.1515/BC.2007.045. PMID 17391060. S2CID 37492665.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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