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HLA-A43

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Human leukocyte antigen serotype
HLA-A43
(MHC Class I, A cell surface antigen)
HLA-A43
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*4301, β2-microglobulin
Older namesA10
Subtypes
Subtype allele Available structures
A43 *4301
{{{cNick2}}} *43{{{cAllele2}}}
{{{cNick3}}} *43{{{cAllele3}}}
{{{cNick4}}} *43{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A43 (A43) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α subset of HLA-A α-chains. For A43, the alpha "A" chain are encoded by the HLA-A*43 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*4301. A43 and A*43 are almost synonymous in meaning. A43 is a split antigen of the broad antigen serotype A10. A43 is a sister serotype of A25, A26, A34, and A66.

Further information: History and naming of human leukocyte antigens

A43 is more common in Africa and SouthWest Asia. A43 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele..

Serotype

A43 recognition of some HLA A*43 gene products
A*43 A43 A26 Sample
allele % % size (N)
*4301 0 35 9

A43 serotyping is poor.

Distribution

HLA A*4301 frequencies
freq
ref. Population (%)
South Africa Tswana 4.9
South African Natal Zulu 3.0
China Yunnan Han 1.2
Zambia Lusaka 1.2
Pakistan Karachi Parsi 0.6
India North Delhi 0.5
Zimbabwe Harare Shona 0.4
Italy 0.01
China Shanghai 0.002

References

  1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
  3. Allele Query Form IMGT/HLA - European Bioinformatics Institute
  4. ^ Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
HLA-A serotypes
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