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IFT81
Identifiers
Aliases	IFT81, CDV-1, CDV-1R, CDV1, CDV1R, DV1, intraflagellar transport 81, SRTD19
External IDs	OMIM: 605489; MGI: 1098597; HomoloGene: 7664; GeneCards: IFT81; OMA:IFT81 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.11 Start 110,124,335 bp End 110,218,793 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 62.44 cM Start 122,688,267 bp End 122,752,581 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell ventricular zone right uterine tube ganglionic eminence Achilles tendon olfactory zone of nasal mucosa testicle Epithelium of choroid plexus left testis right testis Top expressed in spermatid saccule spermatocyte neural layer of retina interventricular septum genital tubercle otic vesicle vestibular sensory epithelium right ventricle olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function tubulin binding protein binding Cellular component intraciliary transport particle B ciliary basal body centrosome sperm principal piece cell projection ciliary tip motile cilium sperm midpiece cilium Biological process cell projection organization spermatogenesis intraciliary transport intraciliary transport involved in cilium assembly cilium assembly regulation of smoothened signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28981 12589 Ensembl ENSG00000122970 ENSMUSG00000029469 UniProt Q8WYA0 O35594 RefSeq (mRNA) NM_001143779 NM_014055 NM_031473 NM_001347946 NM_001347947 NM_001347948 NM_009879 NM_001358917 NM_001358918 NM_001358919 RefSeq (protein) NP_001137251 NP_054774 NP_113661 NP_001334875 NP_001334876 NP_001334877 NP_001137251.1 NP_054774.2 NP_034009 NP_001345846 NP_001345847 NP_001345848 Location (UCSC) Chr 12: 110.12 – 110.22 Mb Chr 5: 122.69 – 122.75 Mb PubMed search
Wikidata
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Intraflagellar transport protein 81 homolog is a protein that in humans is encoded by the IFT81 gene. Together with IFT74/72 it forms a core complex to build IFT particles which are required for cilium formation. Additionally, it interacts with basal body components as CEP170 which regulates the disassembly of the cilium.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000122970 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029469 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: intraflagellar transport 81 homolog (Chlamydomonas)".
6. Higashi M, Kobayashi K, Iijima M, Wakana S, Horiuchi M, Yasuda T, Yoshida G, Kanmura Y, Saheki T (December 2000). "Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene". Mamm. Genome. 11 (12): 1053–7. doi:10.1007/s003350010207. PMID 11130971. S2CID 9319574.
7. Lucker BF, Behal RH, Qin H, Siron LC, Taggart WD, Rosenbaum JL, Cole DG (July 2005). "Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits". J. Biol. Chem. 280 (30): 27688–96. doi:10.1074/jbc.M505062200. PMID 15955805.
8. Lamla, Stefan (2009). Functional characterisation of the centrosomal protein Cep170 (Thesis). LMU München: Faculty of Biology.

Further reading

• Melzer D, Perry JR, Hernandez D, et al. (2008). Cheung VG (ed.). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genet. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913. [REDACTED]
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Peng J, Yu L, Horiuchi M, et al. (2002). "Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation". Mol. Biol. Rep. 29 (4): 353–62. doi:10.1023/A:1021232518628. PMID 12549821. S2CID 908688.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

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