MDE may refer to:
Education
- Master of Distance Education (MDE), a graduate degree offered by Athabasca University, Canada
- Michigan Department of Education, a state agency of Michigan, US
- Minnesota Department of Education, a state agency of Minnesota, US
- Mississippi Department of Education, a state agency of Mississippi, US
Science
- Major depressive episode
- Methylenedioxyethylamphetamine, a psychoactive drug
- Mid-domain effect spatial/area hypotheses to explain Latitudinal gradients in species diversity
- Methylenedioxyephedrone also known as MDE
Technology
- Model-driven engineering, the systematic use of models as primary engineering artifacts
- Multi-disciplinary Engineering, an extrapolated version of systems engineering
- In Microsoft Access, mde, the file extension for protected (compiled) databases
- Microsoft Device Emulator, an emulator for Windows Mobile-based devices
- Mitsubishi Design Europe, the design studio of Mitsubishi Motors Europe
Other uses
- Million Dollar Extreme, a comedy sketch group
- Maximum Downside Exposure, values the maximum downside to the portfolio
- Markit Document Exchange, platform used by financial market participants for distribution of account onboarding or KYC documents
- José María Córdova International Airport (IATA code: MDE), an airport in Colombia
- Major Deegan Expressway in New York City
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