MTB may refer to:
Science and medicine
- Magnetotactic bacteria
- Mediterranean tamarisk beetle
- Multilobular tumour of bone, canine disease
- Mycobacterium tuberculosis
Transport and vehicles
- Matlock Bath railway station, England; National Rail station code MTB
- Mississauga Truck and Bus Collision, a Canadian bus manufacturer
- Motor torpedo boat
- Mountain bike
Other uses
- Magandang Tanghali Bayan, a variety show in the Philippines
- M&T Bank of New York, NYSE symbol
- My Therapy Buddy, a talking plush doll for adults
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