NCF1C - Misplaced Pages

Pseudogene in the species Homo sapiens

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NCF1C

Identifiers

Aliases

NCF1C, SH3PXD1C, neutrophil cytosolic factor 1C pseudogene

External IDs

GeneCards: NCF1C; OMA:NCF1C - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q11.23	Start	75,156,639 bp
Band	7q11.23	End	75,172,044 bp

Orthologs

Species

Human

Mouse

Entrez


654817


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Ensembl


ENSG00000165178


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UniProt


n a


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

Chr 7: 75.16 – 75.17 Mb

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PubMed search

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Wikidata

View/Edit Human

NCF1C is a human pseudogene related to NCF1 (neutrophil cytosol factor 1), the latter being responsible for encoding the 47 kDA cytosolic subunit of NADPH oxidase. In chronic granulomatous disease, the functional NCF1 gene recombines with the two nearby pseudogenes (NCF1B, NCF1C) and becomes inactivated.

References

^ GRCh38: Ensembl release 89: ENSG00000165178 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"NCF1C neutrophil cytosolic factor 1C pseudogene [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-17.
Merling RK, Kuhns DB, Sweeney CL, Wu X, Burkett S, Chu J, et al. (January 2017). "Gene-edited pseudogene resurrection corrects p47-deficient chronic granulomatous disease". Blood Advances. 1 (4): 270–278. doi:10.1182/bloodadvances.2016001214. PMC 5727772. PMID 29296942.

References

Further reading