Nikkomycins are a group of antifungal medications. They work by interfering with the building of the fungal cell wall which results in the fungal cell breaking open. They were discovered in 1976. The specific agent nikkomycin Z has weak activity against Aspergillus fumigatus which may be of benefit when used with other medications, such as caspofungin, ranconazole and amphotericin B, fluconazole or itraconazole. Nikkomycin Z also inhibits growth of Batrachochytrium dendrobatidis, a serious fungal pathogen linked to global amphibian declines, while lower concentrations of Nikkomycin Z enhanced natural amphibian antimicrobial skin peptide effectiveness in vitro.
Originally identified from Streptomyces tendae, the nikkomycins are chitin synthase inhibitors.
References
- ^ Steinbach, WJ; Stevens, DA (1 October 2003). "Review of newer antifungal and immunomodulatory strategies for invasive aspergillosis". Clinical Infectious Diseases. 37 (Suppl 3): S157-87. doi:10.1086/376523. PMID 12975751.
- ^ Varnava, Kyriakos G.; Ronimus, Ron S.; Sarojini, Vijayalekshmi (November 2017). "A review on comparative mechanistic studies of antimicrobial peptides against archaea". Biotechnology and Bioengineering. 114 (11): 2457–2473. doi:10.1002/bit.26387. PMID 28734066. S2CID 25183554.
- Holden, Whitney M; Fites, J Scott; Reinert, Laura K; Rollins-Smith, Louise A (January 2014). "Nikkomycin Z is an effective inhibitor of the chytrid fungus linked to global amphibian declines". Fungal Biology. 118 (1): 48–60. doi:10.1016/j.funbio.2013.11.001. PMID 24433676. Retrieved 17 June 2021.