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NINL
Identifiers
Aliases	NINL, NLP, dJ691N24.1, ninein like
External IDs	OMIM: 609580; MGI: 1925427; HomoloGene: 57024; GeneCards: NINL; OMA:NINL - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p11.21 Start 25,452,697 bp End 25,585,531 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 G3 Start 150,776,439 bp End 150,881,302 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla ventricular zone cerebellar hemisphere right hemisphere of cerebellum left ovary ganglionic eminence right ovary human kidney right adrenal cortex right lobe of thyroid gland Top expressed in otic vesicle superior cervical ganglion Gonadal ridge spermatocyte tail of embryo ventricular zone olfactory epithelium spermatid abdominal wall hand More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding metal ion binding Cellular component cytoplasm microtubule microtubule organizing center cytosol intercellular bridge cytoskeleton centrosome Biological process G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle microtubule anchoring at centrosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22981 78177 Ensembl ENSG00000101004 ENSMUSG00000068115 UniProt Q9Y2I6 Q6ZQ12 RefSeq (mRNA) NM_025176 NM_001318226 NM_207204 RefSeq (protein) NP_001305155 NP_079452 NP_997087 Location (UCSC) Chr 20: 25.45 – 25.59 Mb Chr 2: 150.78 – 150.88 Mb PubMed search
Wikidata
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Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000101004 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000068115 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
6. "Entrez Gene: RP4-691N24.1 KIAA0980 protein".
7. Casenghi, Martina (2003). Functional characterization of the novel centrosomal protein Nlp (ninein-like protein) (PDF) (Ph.D thesis).

Further reading

• Wang Y, Zhan Q (2007). "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex". J. Biol. Chem. 282 (24): 17712–9. doi:10.1074/jbc.M701350200. PMID 17403670.
• Casenghi M, Barr FA, Nigg EA (2005). "Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome". J. Cell Sci. 118 (Pt 21): 5101–8. doi:10.1242/jcs.02622. PMID 16254247. S2CID 23146359.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

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