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PIGW
Identifiers
Aliases	PIGW, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W
External IDs	OMIM: 610275; MGI: 1917575; HomoloGene: 6243; GeneCards: PIGW; OMA:PIGW - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 36,534,987 bp End 36,539,310 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 C Start 84,767,141 bp End 84,771,111 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans endometrium gastrocnemius muscle testicle appendix rectum skeletal muscle tissue mucosa of esophagus lymph node gonad Top expressed in epiblast lens quadriceps femoris muscle hepatobiliary system liver muscle of thigh white adipose tissue ileum yolk sac tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function acyltransferase activity transferase activity O-acyltransferase activity glucosaminyl-phosphatidylinositol O-acyltransferase activity Cellular component membrane endoplasmic reticulum membrane integral component of membrane endoplasmic reticulum Biological process GPI anchor biosynthetic process GPI anchor metabolic process protein localization to plasma membrane preassembly of GPI anchor in ER membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 284098 70325 Ensembl ENSG00000275600 ENSG00000277161 ENSMUSG00000045140 UniProt Q7Z7B1 Q8C398 RefSeq (mRNA) NM_178517 NM_001346754 NM_001346755 NM_001077636 NM_027388 NM_001363112 RefSeq (protein) NP_001333683 NP_001333684 NP_848612 NP_001071104 NP_081664 NP_001350041 Location (UCSC) Chr 17: 36.53 – 36.54 Mb Chr 11: 84.77 – 84.77 Mb PubMed search
Wikidata
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Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene.

Function

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 ).

References

1. ^ ENSG00000277161 GRCh38: Ensembl release 89: ENSG00000275600, ENSG00000277161 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000045140 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W". Retrieved 2016-10-29.

Further reading

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• Genes on human chromosome 17
• Human chromosome 17 gene stubs