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PLVAP
Identifiers
Aliases	PLVAP, FELS, PV-1, PV1, gp68, plasmalemma vesicle associated protein, DIAR10
External IDs	OMIM: 607647; MGI: 1890497; HomoloGene: 10578; GeneCards: PLVAP; OMA:PLVAP - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 17,351,450 bp End 17,377,342 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 B3.3|8 34.43 cM Start 71,950,409 bp End 71,964,396 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland epithelium of colon gallbladder pericardium cardia tendon of biceps brachii subcutaneous adipose tissue spleen fundus Top expressed in right lung right lung lobe mesenteric lymph nodes atrium right kidney endothelial cell of lymphatic vessel islet of Langerhans left lung spleen internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein homodimerization activity Cellular component cytoplasm perinuclear region of cytoplasm caveola integral component of membrane cell surface plasma membrane extracellular exosome membrane Biological process tumor necrosis factor-mediated signaling pathway protein kinase C signaling MAPK cascade positive regulation of cellular extravasation developmental process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83483 84094 Ensembl ENSG00000130300 ENSMUSG00000034845 UniProt Q9BX97 Q91VC4 RefSeq (mRNA) NM_031310 NM_032398 RefSeq (protein) NP_112600 NP_115774 Location (UCSC) Chr 19: 17.35 – 17.38 Mb Chr 8: 71.95 – 71.96 Mb PubMed search
Wikidata
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Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000130300 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034845 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stan RV, Arden KC, Palade GE (Jun 2001). "cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes". Genomics. 72 (3): 304–13. doi:10.1006/geno.2000.6489. PMID 11401446.
6. "Entrez Gene: PLVAP plasmalemma vesicle associated protein".

Further reading

• Stan RV, Ghitescu L, Jacobson BS, Palade GE (1999). "Isolation, Cloning, and Localization of Rat PV-1, a Novel Endothelial Caveolar Protein". J. Cell Biol. 145 (6): 1189–98. doi:10.1083/jcb.145.6.1189. PMC 2133139. PMID 10366592.
• Hnasko R, McFarland M, Ben-Jonathan N (2003). "Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands". J. Endocrinol. 175 (3): 649–61. CiteSeerX 10.1.1.322.5434. doi:10.1677/joe.0.1750649. PMID 12475376.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Stan RV, Tkachenko E, Niesman IR (2005). "PV1 Is a Key Structural Component for the Formation of the Stomatal and Fenestral Diaphragms". Mol. Biol. Cell. 15 (8): 3615–30. doi:10.1091/mbc.E03-08-0593. PMC 491823. PMID 15155804.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strickland LA, Jubb AM, Hongo JA, et al. (2005). "Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)". J. Pathol. 206 (4): 466–75. doi:10.1002/path.1805. PMID 15971170. S2CID 45045679.
• Carson-Walter EB, Hampton J, Shue E, et al. (2006). "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis". Clin. Cancer Res. 11 (21): 7643–50. doi:10.1158/1078-0432.CCR-05-1099. PMID 16278383.

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