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Ronald Stanton Duman (February 6, 1954 – February 1, 2020) was a Professor of Psychiatry and Pharmacology Director, Division of Molecular Psychiatry and Abraham Ribicoff Research Facilities at Yale University.

Education

Duman graduated from the College of William & Mary (where he played varsity football as a middle linebacker) in 1976. He received his Ph.D. from the University of Texas Health Science Center at Houston (UTHealth) in 1985.

Career

Ron Duman's research centered around the biological mechanisms behind antidepressants. In his landmark 1995 paper, he discovered that antidepressants increase the gene expression of Brain-Derived Neurotrophic Factor, or (BDNF) in the hippocampus. In a later paper he discovered that the downstream effect of BDNF is to increase neurogenesis or the formation of new neurons in the dentate gyrus of the hippocampus.

The results of this work led him to formulate the hypothesis that depression is caused by a decrease in hippocampal neurogenesis caused by elevated cortisol levels.

Death

Ronald Duman died on February 1, 2020, at the age of 65 while hiking in Guilford, Connecticut.

Notes

1. "Ronald Stanton Duman, PhD (Obituary)". The Tribune-Democrat. February 6, 2020. Retrieved February 8, 2020.
2. Duman's Yale Faculty Website Archived 3 June 2009 at the Wayback Machine
3. Pramanick, D.; Forstová, J.; Pivec, L. (1976). "First paper demonstrating the link between antidepressants and BDNF levels". FEBS Letters. 62 (1): 81–84. doi:10.1016/0014-5793(76)80021-x. PMID 2505. S2CID 20044419. Archived from the original on June 22, 2022. Retrieved September 11, 2017.
4. Malberg, J. E.; Eisch, A. J.; Nestler, E. J.; Duman, R. S. (2000). "Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus". The Journal of Neuroscience. 20 (24): 9104–9110. doi:10.1523/JNEUROSCI.20-24-09104.2000. PMC 6773038. PMID 11124987.
5. Ronald S. Duman, PhD, Pioneering Neuroscientist of Stress, Depression, and Antidepressant Treatment Dies at 65

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• 1954 births
• 2020 deaths
• American neuroscientists
• American psychiatrists
• People from Ebensburg, Pennsylvania
• Scientists from Pennsylvania
• University of Texas Health Science Center at Houston alumni
• William & Mary Tribe football players
• Yale School of Medicine faculty
• Members of the National Academy of Medicine
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