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rs5569

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SNP: rs5569
Name(s)A1287G, G1287A
GeneSLC6A2
Chromosome16
RegionExon 9
External databases
EnsemblHuman SNPView
dbSNP5569
HapMap5569
SNPedia5569

In genetics, rs5569 (A1287G or G1287A) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the SLC6A2 gene in exon 9. This gene codes the norepinephrine transporter. The SNP is a silent substitution and the nucleotides of both variants code a threonine amino acid.

Several research studies have examined the effect of the variant in relation to alcohol dependence, attention deficit hyperactivity disorder, diabetes, major depressive disorder, panic disorder, Tourette syndrome and personality traits. None of the studies have found an association.

References

  1. dbSNP
  2. Jerzy Samochowiec, Jolanta Kucharska-Mazur, Ryszard Kaminski, Michael Smolka, Hans Rommelschpacher, Catrin Wernicke, Agnieszka Tymicz & Lutz Gerhardt Schmidt (August 2002). "Norepinephrine transporter gene polymorphism is not associated with susceptibility to alcohol dependence". Psychiatry Research. 111 (2–3): 229–33. doi:10.1016/S0165-1781(02)00145-2. PMID 12374639. S2CID 6493515.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. San-Yuan Huang, Ru-Band Lu, Kuo-Hsing Ma, Mee-Jen Shy & Wei-Wen Lin (January 2008). "Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups". Drug and Alcohol Dependence. 92 (1–3): 20–26. doi:10.1016/j.drugalcdep.2007.06.003. PMID 17630229.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Soo-Churl Cho, Jae-Won Kim, Boong-Nyun Kim, Jun-Won Hwang, Mira Park, Soon Ae Kim, Dae-Yeon Cho, Hee-Jeong Yoo, Un-Sun Chung, Jung-Woo Son & Tae-Won Park (2008). "No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample". Neuropsychobiology. 57 (3): 131–138. doi:10.1159/000138916. PMID 18552510. S2CID 7062834.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Piotr Ksiazek, Kinga Buraczynska & Monika Buraczynska (2006). "Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes". Kidney and Blood Pressure Research. 29 (6): 338–43. doi:10.1159/000097356. PMID 17124432. S2CID 25727749.
  6. Peter Zill, Rolf Engel, Thomas C. Baghai, Georg Juckel, Thomas Frodl, Florian Muller-Siecheneder, Peter Zwanzger, Cornelius Schule, Christo Minov, Stefanie Behrens, Rainer Rupprecht, Ulrich Hegerl, Hans Jurgen Moller & Brigitta Bondy (April 2002). "Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression". Neuropsychopharmacology. 26 (4): 489–93. doi:10.1016/S0893-133X(01)00386-4. PMID 11927173.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. Kazuyuki Inoue, Kunihiko Itoh, Keizo Yoshida, Hisashi Higuchi, Mitsuhiro Kamata, Hitoshi Takahashi, Tetsuo Shimizu & Toshio Suzuki (October 2007). "No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population". Biological & Pharmaceutical Bulletin. 30 (10): 1996–1998. doi:10.1248/bpb.30.1996. PMID 17917281.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. P. G. Sand, T. Mori, C. Godau, G. Stober, P. Flachenecker, P. Franke, M. M. Nothen, J. Fritze, W. Maier, K.-P. Lesch, P. Riederer, H. Beckmann & J. Deckert (November 2002). "Norepinephrine transporter gene (NET) variants in patients with panic disorder". Neuroscience Letters. 333 (1): 41–44. doi:10.1016/S0304-3940(02)00984-9. PMID 12401556. S2CID 19657809.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. Christopher A. Rippel, Andrew J. Kobets, Dustin Y. Yoon, Phillip N. Williams, Yin Yao Shugart, Dana D. Bridges, David J. Vandenbergh & Harvey S. Singer (October 2006). "Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association". Psychiatric Genetics. 16 (5): 179–80. doi:10.1097/01.ypg.0000218622.96127.71. PMID 16969268.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. J. Samochowiec, F. Rybakowski, P. Czerski, M. Zakrzewska, G. Stepien, J. Pelka-Wysiecka, J. Horodnicki, J. K. Rybakowski & J. Hauser (2001). "Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers". Neuropsychobiology. 43 (4): 248–53. doi:10.1159/000054898. PMID 11340364. S2CID 24521817.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

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